99mTc-MIBI stress-rest myocardial perfusion scintigraphy in patients with complete left bundle branch block

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dc.contributor.authorEllmann A.
dc.contributor.authorVan Heerden P.D.R.
dc.contributor.authorVan Heerden B.B.
dc.contributor.authorKlopper J.F.
dc.date.accessioned2011-05-15T16:15:55Z
dc.date.available2011-05-15T16:15:55Z
dc.date.issued2001
dc.description.abstractBackground. Patients with complete left bundle branch block (LBBB) often show a false-positive ischaemic pattern in the interventricular septum on thallium-201 (201Tl) stress-rest myocardial perfusion scintigraphy. Equivocal results have been reported with technetium-99m labelled hexakis-methoxyisobutyl isonitrile (99mTc-MIBI) in such patients. The aim of this retrospective study was to determine the effect of LBBB on the septal uptake of 99mTc-MIBI during stress-rest single photon emission computed tomography (SPECT) scintigraphy. Methods. We studied 75 consecutive patients with LBBB, referred for 99mTc-MIBI stress-rest SPECT. Studies were evaluated by visual analysis using a semi-quantitative grading technique. In all patients with abnormal septal segments, the presence or absence of ischaemic heart disease was confirmed either clinically or by means of angiographical examination. Results. Forty-three patients (57.3%) had completely normal studies. Only 15 (20%) had septal abnormalities (11 with reversible and 4 with fixed defects), while 17 patients (22.7%) had abnormal segments in areas other than the interventricular septum. Except for 1 patient lost to follow-up, ischaemic heart disease was confirmed in all the patients with septal changes. Conclusion. We conclude that 99mTc-MIBI is more specific than 201Tl for identifying ischaemic heart disease in the presence of LBBB.
dc.description.versionArticle
dc.identifier.citationCardiovascular Journal of South Africa
dc.identifier.citation12
dc.identifier.citation5
dc.identifier.issn10159657
dc.identifier.urihttp://hdl.handle.net/10019.1/13548
dc.subjectmethoxy isobutyl isonitrile technetium tc 99m
dc.subjectthallium 201
dc.subjectdiagnostic agent
dc.subjectradiopharmaceutical agent
dc.subjectadult
dc.subjectaged
dc.subjectangiocardiography
dc.subjectarticle
dc.subjectelectrocardiography
dc.subjectheart left bundle branch block
dc.subjectheart scintiscanning
dc.subjecthuman
dc.subjectischemic heart disease
dc.subjectmajor clinical study
dc.subjectsingle photon emission computer tomography
dc.subjectexercise test
dc.subjectfollow up
dc.subjectheart
dc.subjectheart bundle branch block
dc.subjectheart muscle ischemia
dc.subjectheart septum defect
dc.subjectincidence
dc.subjectperfusion
dc.subjectretrospective study
dc.subjectscintiscanning
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBundle-Branch Block
dc.subjectCoronary Angiography
dc.subjectExercise Test
dc.subjectFollow-Up Studies
dc.subjectHeart
dc.subjectHeart Septal Defects
dc.subjectHuman
dc.subjectIncidence
dc.subjectMiddle Age
dc.subjectMyocardial Ischemia
dc.subjectPerfusion
dc.subjectRadiopharmaceuticals
dc.subjectRetrospective Studies
dc.subjectTechnetium Tc 99m Sestamibi
dc.subjectTomography, Emission-Computed, Single-Photon
dc.title99mTc-MIBI stress-rest myocardial perfusion scintigraphy in patients with complete left bundle branch block
dc.typeArticle
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