Comparison of diagnostic criteria of tuberculous meningitis in human immunodeficiency virus-infected and uninfected children

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dc.contributor.authorVan Der Weert E.M.
dc.contributor.authorHartgers N.M.
dc.contributor.authorSchaaf H.S.
dc.contributor.authorEley B.S.
dc.contributor.authorPitcher R.D.
dc.contributor.authorWieselthaler N.A.
dc.contributor.authorLaubscher R.
dc.contributor.authorDonald P.R.
dc.contributor.authorSchoeman J.F.
dc.date.accessioned2011-05-15T16:00:07Z
dc.date.available2011-05-15T16:00:07Z
dc.date.issued2006
dc.description.abstractINTRODUCTION: Tuberculous (TB) meningitis is sometimes difficult to diagnose in young children. The decision to start anti-TB treatment of TB meningitis is usually made on clinical grounds and results of special investigations, such as cerebrospinal fluid examination and cranial computerized tomography (CT), because bacteriologic yield is low and the results delayed. AIM: To determine whether the clinical, laboratory, and radiologic criteria used in the diagnosis of TB meningitis in human immunodeficiency virus (HIV)-uninfected children apply to HIV-infected children. METHODS: Retrospective, case-control study. Clinical, laboratory, and radiologic features of TB meningitis were compared in 34 HIV-infected and 56 HIV-uninfected patients matched for age and stage of TB meningitis. RESULTS: All clinical differences found between the 2 groups at admission were related to the underlying HIV disease. Neurologic presentation and cerebrospinal fluid findings at admission did not differ significantly between the 2 groups. Significantly more HIV-infected than HIV-uninfected children had evidence of TB on chest radiography. The classic CT signs of TB meningitis (obstructive hydrocephalus and basal enhancement) were significantly less prominent in the HIV-infected group (P < 005). CONCLUSION: The diagnostic criteria for clinical diagnosis of TB meningitis apply to HIV-infected children. However, cranial CT findings in this group may be misleading and delay the diagnosis of TB meningitis. Copyright © 2005 by Lippincott Williams & Wilkins.
dc.description.versionArticle
dc.identifier.citationPediatric Infectious Disease Journal
dc.identifier.citation25
dc.identifier.citation1
dc.identifier.issn8913668
dc.identifier.other10.1097/01.inf.0000183751.75880.f8
dc.identifier.urihttp://hdl.handle.net/10019.1/11535
dc.subjectage distribution
dc.subjectarticle
dc.subjectcase control study
dc.subjectcerebrospinal fluid analysis
dc.subjectchildhood disease
dc.subjectcomparative study
dc.subjectcomputer assisted tomography
dc.subjectcontrolled study
dc.subjectdiagnostic test
dc.subjectdisease severity
dc.subjectfemale
dc.subjecthospital admission
dc.subjecthuman
dc.subjectHuman immunodeficiency virus
dc.subjectHuman immunodeficiency virus infection
dc.subjecthydrocephalus
dc.subjectlaboratory diagnosis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneuroimaging
dc.subjectneurologic disease
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectradiodiagnosis
dc.subjectretrospective study
dc.subjectthorax radiography
dc.subjecttuberculous meningitis
dc.subjectCase-Control Studies
dc.subjectCerebrospinal Fluid
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectInfant
dc.subjectLung
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectTomography, X-Ray Computed
dc.subjectTuberculosis, Meningeal
dc.titleComparison of diagnostic criteria of tuberculous meningitis in human immunodeficiency virus-infected and uninfected children
dc.typeArticle
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