Neutral mononuclear and dinuclear complexes of gold(I) featuring azole ligands: Synthesis, structure and cytotoxicity

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dc.contributor.authorGabrielli W.F.
dc.contributor.authorNogai S.D.
dc.contributor.authorNell M.
dc.contributor.authorCronje S.
dc.contributor.authorRaubenheimer H.G.
dc.date.accessioned2012-04-12T08:17:37Z
dc.date.available2012-04-12T08:17:37Z
dc.date.issued2012
dc.description.abstractThe aim of this work was to extend the small library of existing compounds of gold(I) that contain pentafluorophenyl and thiazole ligands and to determine the biological activity of such compounds against a well-known cancer cell line. Seven mono and dinuclear new compounds that contain imidazole, thiazole and tetrazole rings were isolated and characterised. Three of the crystal structures determined indicated Au...Au interactions between constituent complex molecules. A simple adduct, [Au(C 6F 5)(N-methyl-imidazole)] , exhibits a relatively high anti-tumour specificity indicating the viability of selected phosphine-free gold complexes as cytotoxic agents. © 2012 Elsevier Ltd. All rights reserved.
dc.identifier.citationPolyhedron
dc.identifier.citation34
dc.identifier.citation1
dc.identifier.citation188
dc.identifier.citation197
dc.identifier.issn2775387
dc.identifier.other10.1016/j.poly.2011.12.026
dc.identifier.urihttp://hdl.handle.net/10019.1/20487
dc.subjectAzole
dc.subjectCytotoxicity
dc.subjectGold complexes
dc.subjectHeLa cells
dc.subjectPentafluorophenyl
dc.titleNeutral mononuclear and dinuclear complexes of gold(I) featuring azole ligands: Synthesis, structure and cytotoxicity
dc.typeArticle
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