Cyclosporin as a treatment for interstitial lung disease of unknown aetiology

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dc.contributor.authorMoolman J.A.
dc.contributor.authorBardin P.G.
dc.contributor.authorRossouw D.J.
dc.contributor.authorJoubert J.R.
dc.date.accessioned2011-05-15T16:18:13Z
dc.date.available2011-05-15T16:18:13Z
dc.date.issued1991
dc.description.abstractTen patients with progressive, symptomatic interstitial lung disease of unknown aetiology who were treated with cyclosporin A were reviewed. Five had clinical and histopathological features of cryptogenic fibrosing alveolitis and five a progressive restrictive lung disease characterised by interstitial infiltration with lymphocytes and minimal fibrosis, which could not be classified precisely. Three patients with lymphocytic infiltration showed a response to initial treatment with cyclosporin A alone at high dosage, but toxicity precluded further treatment. All 10 patients then received low doses of cyclosporin A and prednisone. Three of the patients with cryptogenic fibrosing alveolitis and all five patients with lymphocytic infiltration responded with a reduction in dyspnoea or an increase in vital capacity, or both; cyclosporin A appeared to be effective, or at least to have a corticosteroid potentiating effect. A high incidence of side effects occurred, though these do not necessarily prohibit the long term use of cyclosporin A when it is indicated clinically. Cyclosporin A may be effective in the treatment of interstitial lung disease of unknown aetiology. Further studies are required to determine the long term outcome of treatment.
dc.description.versionArticle
dc.identifier.citationThorax
dc.identifier.citation46
dc.identifier.citation8
dc.identifier.issn00406376
dc.identifier.urihttp://hdl.handle.net/10019.1/14565
dc.subjectazathioprine
dc.subjectcyclophosphamide
dc.subjectcyclosporin a
dc.subjectpenicillamine
dc.subjectprednisone
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectfemale
dc.subjectfibrosing alveolitis
dc.subjecthuman
dc.subjectinterstitial lung disease
dc.subjectmale
dc.subjectpriority journal
dc.subjectrestrictive lung disease
dc.subjectAdult
dc.subjectAged
dc.subjectCyclosporine
dc.subjectDrug Therapy, Combination
dc.subjectHuman
dc.subjectMiddle Age
dc.subjectPrednisone
dc.subjectPulmonary Fibrosis
dc.subjectRetrospective Studies
dc.subjectSupport, Non-U.S. Gov't
dc.titleCyclosporin as a treatment for interstitial lung disease of unknown aetiology
dc.typeArticle
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