Interstitial lung disease. Part I. A multidisciplinary approach to the diagnosis and assessment of disease activity

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dc.contributor.authorJoubert, J. R.en_ZA
dc.contributor.authorRossouw, D. J.en_ZA
dc.contributor.authorVan der Walt, J. J.en_ZA
dc.date.accessioned2011-03-18T14:57:48Z
dc.date.available2011-03-18T14:57:48Z
dc.date.issued1980
dc.descriptionCITATION: Joubert, J. R., Rossouw, D. J. & Van der Walt, J. J. 1980. Interstitial lung disease. Part I. A multidisciplinary approach to the diagnosis and assessment of disease activity. South African Medical Journal, 58:435-441.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractThe value of alveolar lavage as an investigative technique was determined in patients with interstitial lung disease. Alveolar cytology was related to defined histopathological degrees of disease activity found in transbronchial biopsy specimens. The degree of disease activity as assessed by these two techniques was compared with radiological evaluation. Adequate specimens of lung tissue for histopathological evaluation were obtained by transbronchial biopsy in 95% of the subjects during the first procedure and diagnostic histopathological changes were found in 60% of the patients. In the evaluation of disease activity, the lymphocyte-macrophage (L-M) ratio and, to a lesser extent, the total alveolar cell counts correlated well with graded histopathological changes of activity. A graded radiological evaluation of activity was accurate in 14 out of 17 patients, but in 3, extreme cellular disease was not recognized. Alveolar cytological examination can be employed as a supplement to the biopsy technique for increased accuracy in the initial and follow-up evaluation of active interstitial lung disease. An approach combining transbronchial biopsy, alveolar lavage and radiography, provides a safe and accurate alternative to open lung biopsy in most patients for determining the aetiology and degree of activity of interstitial lung disease.
dc.description.versionPublisher’s version
dc.format.extent7 pages
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7656
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectLungs -- Diseasesen_ZA
dc.titleInterstitial lung disease. Part I. A multidisciplinary approach to the diagnosis and assessment of disease activityen_ZA
dc.typeArticle
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