Clinical experience with severe acute respiratory syndrome Coronavirus 2-related illness in children : hospital experience in Cape Town, South Africa

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dc.contributor.authorvan der Zalm, Marieke M.en_ZA
dc.contributor.authorLishman, Juanitaen_ZA
dc.contributor.authorVerhagen, Lilly M.en_ZA
dc.contributor.authorRedfern, Andrewen_ZA
dc.contributor.authorSmit, Liezlen_ZA
dc.contributor.authorBarday, Mikhailen_ZA
dc.contributor.authorRuttens, Driesen_ZA
dc.contributor.authorda Costa, A’ishahen_ZA
dc.contributor.authorvan Jaarsveld, Sandraen_ZA
dc.contributor.authorItana, Justinaen_ZA
dc.contributor.authorSchrueder, Neshaaden_ZA
dc.contributor.authorVan Schalkwyk, Marijeen_ZA
dc.contributor.authorParker, Nooren_ZA
dc.contributor.authorAppel, Ilseen_ZA
dc.contributor.authorFourie, Barenden_ZA
dc.contributor.authorClaassen, Mathildaen_ZA
dc.contributor.authorWorkman, Jessica J.en_ZA
dc.contributor.authorGoussard, Pierreen_ZA
dc.contributor.authorVan Zyl, Gerten_ZA
dc.contributor.authorRabie, Helenaen_ZA
dc.date.accessioned2022-06-01T13:20:51Zen_ZA
dc.date.available2022-06-01T13:20:51Zen_ZA
dc.date.issued2020-11-10en_ZA
dc.descriptionCITATION: van der Zalm, M. M. et al. 2021. Clinical Experience With Severe Acute Respiratory Syndrome Coronavirus 2-Related Illness in Children: Hospital Experience in Cape Town, South Africa. Clinical infectious diseases, 72(12):e938–e944. doi:10.1093/cid/ciaa1666en_ZA
dc.descriptionThe original publication is available at https://academic.oup.com/cid/en_ZA
dc.description.abstractBackground: Children seem relatively protected from serious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease, but little is known about children living in settings with high tuberculosis and human immunodeficiency virus (HIV) burden. This study reflects clinical data on South African children with SARS-CoV-2. Methods: We collected clinical data of children aged <13 years with laboratory-confirmed SARS-CoV-2 presenting to Tygerberg Hospital, Cape Town, between 17 April and 24 July 2020. Results: One hundred fifty-nine children (median age, 48.0 months [interquartile range {IQR}, 12.0-106.0 months]) were included. Hospitalized children (n = 62), with a median age of 13.5 months (IQR, 1.8-43.5 months) were younger than children not admitted (n = 97; median age, 81.0 months [IQR, 34.5-120.5 months]; P < .01.). Thirty-three of 159 (20.8%) children had preexisting medical conditions. Fifty-one of 62 (82.3%) hospitalized children were symptomatic; lower respiratory tract infection was diagnosed in 21 of 51 (41.2%) children, and in 11 of 16 (68.8%) children <3 months of age. Respiratory support was required in 25 of 51 (49.0%) children; 13 of these (52.0%) were <3 months of age. One child was HIV infected and 11 of 51 (21.2%) were HIV exposed but uninfected, and 7 of 51 (13.7%) children had a recent or new diagnosis of tuberculosis. Conclusions: Children <1 year of age hospitalized with SARS-CoV-2 in Cape Town frequently required respiratory support. Access to oxygen may be limited in some low- and middle-income countries, which could potentially drive morbidity and mortality. HIV infection was uncommon but a relationship between HIV exposure, tuberculosis, and SARS-CoV-2 should be explored.en_ZA
dc.description.urihttps://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac266/6591403en_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent7 pagesen_ZA
dc.identifier.citationCITATION: van der Zalm, M. M. et al. 2021. Clinical Experience With Severe Acute Respiratory Syndrome Coronavirus 2-Related Illness in Children: Hospital Experience in Cape Town, South Africa. Clinical infectious diseases, 72(12):e938–e944. doi:10.1093/cid/ciaa1666en_ZA
dc.identifier.issn1537-6591 (online)en_ZA
dc.identifier.issn1058-4838 (print)en_ZA
dc.identifier.otherdoi:10.1093/cid/ciaa1666en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125297en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherOxford University Pressen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectCOVID-19 (Disease) -- Cape Townen_ZA
dc.subjectAcute respiratory syndrome, Severeen_ZA
dc.subjectRespiratory therapy for childrenen_ZA
dc.subjectRespiratory virus infectionsen_ZA
dc.subjectChildren -- Mortality -- Sub-Saharan Africaen_ZA
dc.subjectCommunicable diseasesen_ZA
dc.titleClinical experience with severe acute respiratory syndrome Coronavirus 2-related illness in children : hospital experience in Cape Town, South Africaen_ZA
dc.typeArticleen_ZA
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