A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney disease

Simple item page
dc.contributor.authorChothia, Yazieden_ZA
dc.contributor.authorKassum, Patriciaen_ZA
dc.contributor.authorZemlin, Annalise Een_ZA
dc.date.accessioned2022-04-23T10:03:08Z
dc.date.available2022-04-23T10:03:08Z
dc.date.issued2020-07
dc.description.abstractIntroduction: Hyperkalaemia is a common electrolyte disorder that may cause life-threatening cardiac arrythmias. We aimed to determine the agreement of potassium concentrations between GEM premier 3500 point-of-care blood gas analyser (POC-BGA) and Roche Cobas 6000 c501 auto-analyser in patients with hyperkalaemia. Methods: A prospective, cross-sectional study of all consecutive adult patients referred to the Renal Unit with a serum potassium concentration ≥ 5.5 mmol/L was performed. A total of 59 paired venous blood samples were included in the final statistical analysis. Passing-Bablok regression and Bland Altman analysis were used to compare the two methods. Results: The median laboratory auto-analyser potassium concentration was 6.1 (5.9-7.1) mmol/L as compared to the POC-BGA potassium concentration of 5.7 (5.5-6.8) mmol/L with a mean difference of - 0.43 mmol/L and 95% upper and lower limits of agreement of 0.35 mmol/L and - 1.21 mmol/L, respectively. Regression analysis revealed proportional systematic error. Test for linearity did not indicate significant deviation (P = 0.297). Conclusion: Although regression analysis indicated proportional systematic error, on Bland Altman analysis, the mean difference appeared to remain relatively constant across the potassium range that was evaluated. Therefore, in patients presenting to the emergency department with a clinical suspicion of hyperkalaemia, POC-BGA potassium concentrations may be considered a surrogate for laboratory auto-analyser measurements once clinicians have been cautioned about this difference.en_ZA
dc.format.extent7 pages
dc.identifier.citationdoi.org/10.11613/BM.2020.030702
dc.identifier.urihttp://hdl.handle.net/10019.1/124464
dc.language.isoen_ZAen_ZA
dc.rightsAuthors retain copyright
dc.subjectpoint-of-careen_ZA
dc.subjectemergency departmenten_ZA
dc.subjectpotassium concentrationsen_ZA
dc.subjecthyperkalaemiaen_ZA
dc.titleA method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney diseaseen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Chotia_Kassum_Zemlin_A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser_2020.pdf
Size:
257.98 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Chemical Pathology)