Islet cell function in long-term surviving primates after segmental pancreatic allotransplantation

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dc.contributor.authorDu Toit D.F.
dc.contributor.authorHeydenrych J.
dc.contributor.authorSmit B.
dc.contributor.authorVan der Merwe E.
dc.contributor.authorLouw G.
dc.contributor.authorZuurmond T.
dc.contributor.authorEls D.
dc.contributor.authorWeideman A.
dc.contributor.authorDu Toit L.
dc.contributor.authorWolfe-Coote S.
dc.contributor.authorDavids H.
dc.date.accessioned2011-05-15T16:05:05Z
dc.date.available2011-05-15T16:05:05Z
dc.date.issued1988
dc.description.abstractIslet cell function was studied in pancreatectomized primates with functioning segmental pancreatic allografts more than 100 days after transplantation. Segmental allograft recipients were immunosuppressed with total lymphoid irradiation (TL1) and cyclosporine (SCA). After 100 days, islet function was assessed, at which stage immunosuppression was terminated. Glucose, insulin, glucagon, and C-peptide response was assessed during intravenous glucose tolerance test (IVGTT) and during arginine and tolbutamide stimulation. In eight normoglycaemic primates in which immunosuppressive treatment had been stopped and with mean graft survival of 145 days, islet stimulation was associated with moderate glucose intolerance, reduced K-values, hypoinsulinaemia, and low C-peptide values. Postmortem findings in all animals intentionally killed revealed severe graft atrophy in the absence of significant rejection. Severe graft atrophy in normoglucaemic primates, together with significantly impaired graft function after segmental pancreatic transplantation compared to normal animals, suggest that transplantation of the whole pancreas may be mandatory if normal or near-normal function is to be achieved.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation38
dc.identifier.citation1
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12965
dc.subjectc peptide
dc.subjectcyclosporin
dc.subjectglucagon
dc.subjectglucose
dc.subjectinsulin
dc.subjecttolbutamide
dc.subjectanimal experiment
dc.subjectautopsy
dc.subjectglucose tolerance test
dc.subjectgraft survival
dc.subjectintramuscular drug administration
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectoral drug administration
dc.subjectpancreas islet
dc.subjectpancreas transplantation
dc.subjectpriority journal
dc.subjectAnimal
dc.subjectAtrophy
dc.subjectComparative Study
dc.subjectFemale
dc.subjectGraft Survival
dc.subjectImmunosuppression
dc.subjectIslets of Langerhans
dc.subjectMale
dc.subjectPancreas
dc.subjectPancreas Transplantation
dc.subjectPancreatectomy
dc.subjectPancreatic Function Tests
dc.subjectPapio
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTime Factors
dc.subjectTransplantation, Homologous
dc.titleIslet cell function in long-term surviving primates after segmental pancreatic allotransplantation
dc.typeArticle
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