Neuroimaging markers of human immunodeficiency virus infection in South Africa

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dc.contributor.authorHeaps J.M.
dc.contributor.authorJoska J.
dc.contributor.authorHoare J.
dc.contributor.authorOrtega M.
dc.contributor.authorAgrawa A.
dc.contributor.authorSeedat S.
dc.contributor.authorAnces B.M.
dc.contributor.authorStein D.J.
dc.contributor.authorPaul R.
dc.date.accessioned2012-07-26T07:16:18Z
dc.date.available2012-07-26T07:16:18Z
dc.date.issued2012
dc.descriptionArticle
dc.description.abstractPrevious studies have reported cognitive deficits among HIV-positive individuals infected with clade C virus. However, no study has examined whether individuals predominately infected with clade C virus exhibit brain atrophy relative to healthy controls. This study examined volumetric differences between 28 HIV+ individuals and 23 HIV? controls from South Africa. Volumetric measures were obtained from six regions of interest - caudate, thalamus, corpus callosum, total cortex, total gray matter, and total white matter. HIV+ participants had significantly lower volumes in the total white matter (p<0.01), thalamus (p<0.01) and total gray matter (inclusive of cortical and subcortical regions, p<0.01). This study is the first to provide evidence of brain atrophy among HIV+ individuals in South Africa, where HIV clade C predominates. Additional research that integrates neuroimaging, comprehensive neuropsychological testing, genetic variance in clade-specific proteins, and the impact of treatment with Antiretrovirals (ARV) are necessary to understand the development of HIV-related neurocognitive disorders in South Africa. © Journal of NeuroVirology, Inc. 2012.
dc.identifier.citationJournal of NeuroVirology
dc.identifier.citation18
dc.identifier.citation3
dc.identifier.citation151
dc.identifier.citation156
dc.identifier.issn13550284
dc.identifier.otherdoi:10.1007/s13365-012-0090-5
dc.identifier.urihttp://hdl.handle.net/10019.1/21850
dc.subjectClade C virus
dc.subjectHIVinfection
dc.subjectNeuroimaging
dc.subjectSouth Africa
dc.titleNeuroimaging markers of human immunodeficiency virus infection in South Africa
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