Bone mineral density in long-term survivors of childhood cancer

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dc.contributor.authorHesseling P.B.
dc.contributor.authorHough S.F.
dc.contributor.authorNel E.D.
dc.contributor.authorVan Riet F.A.
dc.contributor.authorBeneke T.
dc.date.accessioned2011-05-15T16:16:39Z
dc.date.available2011-05-15T16:16:39Z
dc.date.issued1998
dc.description.abstractBone mineral density (BMD) of the lumbar spine was measured in 97 long-term survivors of childhood cancer 5-23 years after diagnosis using dual-energy X-ray absorptiometry (DXA). They had been treated for acute leukemia (n = 22), brain tumors (n = 16), lymphomas (n = 16), Wilms' tumor (n = 10), neuroblastoma (n = 7) and other cancers (n = 26). The correlations between BMD and the Z-scores for weight for height, height for age and weight for age at diagnosis and follow-up were evaluated with stepwise multiple regression. Correlations with cumulative corticosteroid and radiation dose were examined with Spearman's correlation coefficient. The number and nature of fractures were noted. A BMD Z-score of below -2 was present in 13 and a BMD Z-score of - I to -2 in 31 children. In total, a low BMD was observed in 45% of children. Height for age at follow-up correlated significantly with BMD Z-score. Increasing doses of cranial irradiation (18-54 Gy) were associated with lower BMD (p = 0.001, Spearman). This was true also for 22 children with acute lymphoblastic leukemia (ALL) who had received 18-24 Gy cranial irradiation (p = 0.04, Spearman). Fractures occurred in 14 children following trauma. The difference in BMD Z-scores of children with and without fractures did not achieve statistical significance although the majority of the children with fractures had low BMD Z-scores. The significant inverse correlation between height for age at follow-up and BMD must be interpreted with the realization that DXA is not a volumetric measurement of BMD and that short stature is associated with a smaller skeletal mass. © 1998 Wiley-Liss, Inc.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Cancer
dc.identifier.citation78
dc.identifier.citationSUPPL. 11
dc.identifier.issn00207136
dc.identifier.urihttp://hdl.handle.net/10019.1/13876
dc.subjectcorticosteroid
dc.subjectantineoplastic agent
dc.subjectanalysis of variance
dc.subjectarticle
dc.subjectbody weight
dc.subjectbone density
dc.subjectchild
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjectfracture
dc.subjecthuman
dc.subjectmale
dc.subjectmultimodality cancer therapy
dc.subjectneoplasm
dc.subjectpathophysiology
dc.subjectradiodensitometry
dc.subjectregression analysis
dc.subjectrisk factor
dc.subjectskull irradiation
dc.subjectsurvivor
dc.subjectacute lymphoblastic leukemia
dc.subjectbone mineral
dc.subjectbrain tumor
dc.subjectcancer survival
dc.subjectchildhood cancer
dc.subjectconference paper
dc.subjectdual energy X ray absorptiometry
dc.subjectlumbar spine
dc.subjectlymphoma
dc.subjectmajor clinical study
dc.subjectnephroblastoma
dc.subjectneuroblastoma
dc.subjectpriority journal
dc.subjectAdrenal Cortex Hormones
dc.subjectAnalysis of Variance
dc.subjectBody Weight
dc.subjectBone Density
dc.subjectChild
dc.subjectCombined Modality Therapy
dc.subjectCranial Irradiation
dc.subjectCross-Sectional Studies
dc.subjectDensitometry, X-Ray
dc.subjectFemale
dc.subjectFractures, Bone
dc.subjectHumans
dc.subjectMale
dc.subjectNeoplasms
dc.subjectRegression Analysis
dc.subjectRisk Factors
dc.subjectSurvivors
dc.titleBone mineral density in long-term survivors of childhood cancer
dc.typeArticle
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