Mitochondrial oxidative phosphorylation in myocardial ischaemia: effects of glycerol, glucose and insulin on anoxic hearts perfused at low pressure

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dc.contributor.authorLochner A.
dc.contributor.authorKotze J.C.N.
dc.contributor.authorGevers W.
dc.date.accessioned2011-05-15T15:59:45Z
dc.date.available2011-05-15T15:59:45Z
dc.date.issued1976
dc.description.abstractTo determine whether metabolic intervention could prevent the depression in mitochondrial oxidative phosphorylation resulting from ischaemic perfusion of the isolated rat heart, hearts were perfused with glucose alone, glucose plus insulin, glycerol alone and a combination of glycerol, glucose and insulin. Addition of glucose, as well as glucose plus insulin to perfusates of ischaemic hearts improved mitochondrial oxidative phosphorylation. Perfusions of ischaemic hearts with glycerol, glucose and insulin were most effective: all parameters of mitochondrial function studied were significantly increased.
dc.description.versionArticle
dc.identifier.citationJournal of Molecular and Cellular Cardiology
dc.identifier.citation8
dc.identifier.citation7
dc.identifier.issn222828
dc.identifier.urihttp://hdl.handle.net/10019.1/11345
dc.subjectglucose
dc.subjectglycerol
dc.subjectinsulin
dc.subjectheart
dc.subjectheart mitochondrion
dc.subjectheart muscle cell
dc.subjectheart perfusion
dc.subjecthypoxia
dc.subjectin vitro study
dc.subjectisolated heart
dc.subjectmitochondrion
dc.subjectoxidative phosphorylation
dc.subjectrat
dc.subjecttheoretical study
dc.subjectAnimal
dc.subjectCoronary Disease
dc.subjectDrug Interactions
dc.subjectFatty Acids, Nonesterified
dc.subjectFemale
dc.subjectGlucose
dc.subjectGlycerol
dc.subjectInsulin
dc.subjectMitochondria, Muscle
dc.subjectOxidative Phosphorylation
dc.subjectRats
dc.titleMitochondrial oxidative phosphorylation in myocardial ischaemia: effects of glycerol, glucose and insulin on anoxic hearts perfused at low pressure
dc.typeArticle
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