Assessment of the α/ß ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma

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dc.contributor.authorVernimmen F.J.A.I.
dc.contributor.authorSlabbert J.P.
dc.date.accessioned2011-05-15T16:16:44Z
dc.date.available2011-05-15T16:16:44Z
dc.date.issued2010
dc.description.abstractPurpose: To determine alpha/beta (α/ß) values of arteriovenous malformations (AVM), meningiomas, acoustic neuromas (AN), and the optic chiasma using clinical data. Methods and materials:Data of dose/fractionation schedules form the literature, iso-effective for a specific clinical outcome, were analysed using the Fraction Equivalent plot (FE) method and the Tucker method. Established safe dose/fractionation schedules for the optic chiasma were used to determine its α/ß value. Results:With the FE plot method, an alpha/beta value of 3.76 Gray (Gy) (95 confidence level [CL]: 2.84.6 Gy) for meningiomas, 2.4 Gy (95 CL: 0.83.9 Gy) for acoustic neuroma, and 14.7 Gy (95 CL: 3.825.7 Gy) for arteriovenous malformations were determined. The respective alpha/beta values using the Tucker method were 3.3 Gy (95CL: 2.26.8 Gy), 1.77 Gy (95CL: 1.33.0 Gy) and-57 Gy (95CL:-79.6 to 35.2 Gy). No meaningful α/ß values could be determined for the optic chiasma. Conclusion:Acoustic neuromas with a low α/ß value would show no lesion intrinsic benefit from fractionation. Meningiomas probably benefit from a hypofractionated schedule. The high α/ß value for AVM can be explained but needs further research. Fractionation versus radiosurgery can be considered when the primary objective is to avoid normal tissue damage. © 2010 Informa UK Ltd.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Radiation Biology
dc.identifier.citation86
dc.identifier.citation6
dc.identifier.issn09553002
dc.identifier.other10.3109/09553001003667982
dc.identifier.urihttp://hdl.handle.net/10019.1/13912
dc.subjectacoustic neurinoma
dc.subjectarteriovenous malformation
dc.subjectarticle
dc.subjectcontrolled study
dc.subjecthuman
dc.subjectmeningioma
dc.subjectoptic chiasm
dc.subjectoutcome assessment
dc.subjectpriority journal
dc.subjectradiation dose fractionation
dc.subjectradiation response
dc.subjectradiation safety
dc.subjectradiosurgery
dc.subjecttreatment response
dc.subjectmeta analysis
dc.subjectneuroma
dc.subjectradiation exposure
dc.subjectArteriovenous Malformations
dc.subjectDose Fractionation
dc.subjectHumans
dc.subjectMeningeal Neoplasms
dc.subjectMeningioma
dc.subjectNeuroma, Acoustic
dc.subjectOptic Chiasm
dc.titleAssessment of the α/ß ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma
dc.typeArticle
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