A study of two sequential culture media - Impact on embryo quality and pregnancy rates

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dc.contributor.authorHoogendijk C.F.
dc.contributor.authorKruger T.F.
dc.contributor.authorde Beer M.-L.
dc.contributor.authorSiebert T.I.
dc.contributor.authorHenkel R.
dc.date.accessioned2011-05-15T16:18:04Z
dc.date.available2011-05-15T16:18:04Z
dc.date.issued2007
dc.description.abstractObjective: A comparative study of embryo quality and pregnancy outcome between Sydney IVF medium and Quinn's Advantage sequential culture media. Design: A prospective randomised controlled trial and a retrospective study. Setting: In vitro fertilisation clinic in an academic research environment. Patients: All women < 38 years undergoing fresh embryo transfers. Interventions: Use of clinic specific age, randomisation of patients and embryo score. Main outcome measures: Fertilisation and cleavage rate, embryo quality (day 2 and day 3), blastulation rate and pregnancy rate. Results: Prospective randomised trial: In this study the only significant difference was in day 3 embryo quality (33/79 (42%) v. 40/67 (60%) for Sydney IVF and Quinn's Advantage respectively, p < 0.05). Retrospective study: Significant difference (p < 0.05) for embryo development (early-dividing embryos 156/786 (20%) v. 263/919 (29%)), day 3 good quality (234/639 (37%) v. 378/795 (48%)) and pregnancy rate (ongoing pregnancy rate 31/179 (17%) v. 59/195 (30%)) between Sydney IVF v. Quinn's Advantage sequential culture media. Conclusion: We conclude from these two studies that the range of Quinn's Advantage sequential culture media is more beneficial for in vitro embryo culture as each of the media in the range contribute collectively to more embryos with a better quality. The reason for the significant increase in embryo developmental parameters and pregnancy rate can possibly be attributed to the differences in composition between the two media.
dc.description.versionArticle
dc.identifier.citationSouth African Journal of Obstetrics and Gynaecology
dc.identifier.citation13
dc.identifier.citation2
dc.identifier.issn00382329
dc.identifier.urihttp://hdl.handle.net/10019.1/14494
dc.subjectadult
dc.subjectarticle
dc.subjectblastula
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectculture medium
dc.subjectculture technique
dc.subjectembryo
dc.subjectembryo culture
dc.subjectembryo development
dc.subjectembryo transfer
dc.subjectfemale
dc.subjectfertilization in vitro
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectintermethod comparison
dc.subjectmale
dc.subjectoocyte cleavage
dc.subjectpregnancy rate
dc.subjectrandomized controlled trial
dc.subjectretrospective study
dc.subjectscoring system
dc.titleA study of two sequential culture media - Impact on embryo quality and pregnancy rates
dc.typeArticle
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