Endocrine function after hetero- and ortho-topic segmental pancreatic transplantation in primates

Simple item page
dc.contributor.authorDu Toit D.F.
dc.contributor.authorHeydenrych J.J.
dc.contributor.authorSmit B.
dc.contributor.authorLouw G.
dc.contributor.authorZuurmond T.
dc.contributor.authorEls D.
dc.contributor.authorWeideman A.
dc.contributor.authorWolfe-Coote S.
dc.contributor.authorDu Toit L.
dc.contributor.authorDavids H.
dc.date.accessioned2011-05-15T16:05:05Z
dc.date.available2011-05-15T16:05:05Z
dc.date.issued1988
dc.description.abstractThis study assessed the early postoperative pancreatic endocrine function after intraperitoneal segmental hetero- and ortho-topic pancreatic allo-transplantation in hemipancreatectomized, nonimmunesuppressed chacma baboons. Hemipancreatectomized animals remained normoglycaemic but rendered significantly reduced K values and insulin release during IVGTT, findings consistent with major pancreatic resection. Segmental hetero- or ortho-topic pancreatic transplantation did not improve reduced K values and hypoinsulinaemia following hemipancreatectomy although orthotopically sited grafts rendered the best glucose tolerance test curves. Glucagon output during IVGTT remained the same in both transplant models. It is concluded that the postoperative hormonal response was similar in both orthotopic and heterotopic transplant recipients, which indicates that drainage of graft venous effluent into the portal circulation has no advantage over systemic insulin drainage as reflected in this 'diabetic' model.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation37
dc.identifier.citation3
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12962
dc.subjectanimal experiment
dc.subjectglucose tolerance test
dc.subjectinsulin release
dc.subjectmethodology
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectpancreas resection
dc.subjectpancreas transplantation
dc.subjectAnimal
dc.subjectBlood Glucose
dc.subjectFemale
dc.subjectGlucagon
dc.subjectGlucose Tolerance Test
dc.subjectInsulin
dc.subjectIslets of Langerhans
dc.subjectMale
dc.subjectPancreas Transplantation
dc.subjectPancreatectomy
dc.subjectPapio
dc.subjectSupport, Non-U.S. Gov't
dc.titleEndocrine function after hetero- and ortho-topic segmental pancreatic transplantation in primates
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications