A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia
Date
1993
Authors
Hatfill S.J.
La Cock C.J.R.
Laubscher R.
Downing T.G.
Kirby R.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the bone marrow create hematological defects similar to sMDS, and abnormal dimers of mt DNA are observed in acute leukemia. This suggests a role for mt DNA in the pathogenesis of sMDS and secondary leukemia. We outline disparate experimental evidence to support this concept and suggest a role for select protease inhibitors in the clinical management of this disorder.
Description
Keywords
alkylating agent, antipain, chloramphenicol, leupeptin, mitochondrial dna, proteinase inhibitor, adult, bone marrow, dimerization, gene deletion, human, lymphocyte transformation, male, myelodysplasia, myelodysplastic syndrome, preleukemia, priority journal, radiation carcinogenesis, review, Bone Marrow, DNA, Mitochondrial, Human, Leukemia, Radiation-Induced, Myelodysplastic Syndromes, Preleukemia, Sequence Deletion
Citation
Leukemia Research
17
11
17
11