The potential role of regulatory genes (DNMT3A, HDAC5, and HDAC9) in antipsychotic treatment response in South African schizophrenia patients

Simple item page
dc.contributor.authorO’Connell, Kevin Seanen_ZA
dc.contributor.authorMcGregor, Nathaniel Wadeen_ZA
dc.contributor.authorEmsley, Robin A.en_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.contributor.authorWarnich, Louiseen_ZA
dc.date.accessioned2019-08-21T13:29:42Z
dc.date.available2019-08-21T13:29:42Z
dc.date.issued2019-10-07
dc.descriptionCITATION: O’Connell, K. S., et al. 2019. The potential role of regulatory genes (DNMT3A, HDAC5, and HDAC9) in antipsychotic treatment response in South African schizophrenia patients. Frontiers in Genetics, 10:641, doi:10.3389/fgene.2019.00641.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractENGLISH ABSTRACT: Despite advances in pharmacogenetics, the majority of heritability for treatment response cannot be explained by common variation, suggesting that factors such as epigenetics may play a key role. Regulatory genes, such as those involved in DNA methylation and transcriptional repression, are therefore excellent candidates for investigating antipsychotic treatment response. This study explored the differential expression of regulatory genes between patients with schizophrenia (chronic and antipsychotic-naïve first-episode patients) and healthy controls in order to identify candidate genes for association with antipsychotic treatment response. Seven candidate differentially expressed genes were identified, and four variants within these genes were found to be significantly associated with treatment response (DNMT3A rs2304429, HDAC5 rs11079983, and HDAC9 rs1178119 and rs11764843). Further analyses revealed that two of these variants (rs2304429 and rs11079983) are predicted to alter the expression of specific genes (DNMT3A, ASB16, and ASB16-AS1) in brain regions previously implicated in schizophrenia and treatment response. These results may aid in the development of biomarkers for antipsychotic treatment response, as well as novel drug targets.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fgene.2019.00641/full
dc.description.versionPublisher's version
dc.format.extent9 pagesen_ZA
dc.identifier.citationO’Connell, K. S., et al. 2019. The potential role of regulatory genes (DNMT3A, HDAC5, and HDAC9) in antipsychotic treatment response in South African schizophrenia patients. Frontiers in Genetics, 10:641, doi:10.3389/fgene.2019.00641
dc.identifier.issn1664-8021 (online)
dc.identifier.otherdoi:10.3389/fgene.2019.00641
dc.identifier.urihttp://hdl.handle.net/10019.1/106370
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectSchizophreniaen_ZA
dc.subjectEpigeneticsen_ZA
dc.subjectAntipsychotic drugsen_ZA
dc.titleThe potential role of regulatory genes (DNMT3A, HDAC5, and HDAC9) in antipsychotic treatment response in South African schizophrenia patientsen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
oconnell_potential_2019.pdf
Size:
1.13 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Psychiatry)