Comparative trial of clomiphene citrate/human menopausal gonadotropin and the contraceptive pill, followed by clomiphene citrate/human menopausal gonadotropin, in a gamete intrafallopian transfer program

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dc.contributor.authorKruger T.F.
dc.contributor.authorFisher A.
dc.contributor.authorSwart Y.
dc.contributor.authorVan der Merwe J.P.
dc.contributor.authorSmith K.
dc.date.accessioned2011-05-15T16:16:52Z
dc.date.available2011-05-15T16:16:52Z
dc.date.issued1993
dc.description.abstractPurpose: It may sometimes be necessary to regulate cycles in assisted reproduction. Cycles can be regulated with gonadotropin releasing hormone (GnRHa) agonist but other methods can also be used. The aim of this study was to compare the pregnancy rate in a gamete intrafallopian transfer (GIFT) program in patients receiving a contraceptive pill/Clomid/human menopausal gonadotropin (hMG) regimen (study group), with the standard Clomid/hMG regime (control group). Fifty one patients in the study group were carefully matched for patient age, infertility diagnosis (female), semen parameters, number of follicles, and number of oocytes transferred into consideration with a control group. Results: The overall pregnancy rate was 21.6% (11/51) in the study group and 47% (24/51) in the control group (P = 0.01). However, the ongoing pregnancy rate in the two groups did not differ significantly, 11.8% (6/51) vs 27.5% (14/51) (P = 0.08). In the study group, 7.8% of patients had to be seen over a weekend, compared to 13.7% in the control group (not significant). Conclusion: From the findings we conclude that, although this method of controlling cycles can be useful in selected patients, it is not the ultimate method.
dc.description.versionArticle
dc.identifier.citationJournal of Assisted Reproduction and Genetics
dc.identifier.citation10
dc.identifier.citation2
dc.identifier.issn10580468
dc.identifier.urihttp://hdl.handle.net/10019.1/13967
dc.subjectchorionic gonadotropin
dc.subjectclomifene citrate
dc.subjectdesogestrel
dc.subjectdesogestrel plus ethinylestradiol
dc.subjectethinylestradiol
dc.subjecthuman menopausal gonadotropin
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfemale infertility
dc.subjectgamete intrafallopian transfer
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmenstrual cycle
dc.subjectoral drug administration
dc.subjectovulation induction
dc.subjectpregnancy rate
dc.subjectAdult
dc.subjectClomiphene
dc.subjectComparative Study
dc.subjectDesogestrel
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectGamete Intrafallopian Transfer
dc.subjectHuman
dc.subjectInfertility, Female
dc.subjectMale
dc.subjectMenotropins
dc.subjectOvulation Induction
dc.subjectPregnancy
dc.subjectRetrospective Studies
dc.titleComparative trial of clomiphene citrate/human menopausal gonadotropin and the contraceptive pill, followed by clomiphene citrate/human menopausal gonadotropin, in a gamete intrafallopian transfer program
dc.typeArticle
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