Acute stroke in a child with miliary tuberculosis

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dc.contributor.authorSchoeman J.F.
dc.contributor.authorRutherfoord G.S.
dc.contributor.authorHewlett R.H.
dc.date.accessioned2011-05-15T16:16:06Z
dc.date.available2011-05-15T16:16:06Z
dc.date.issued1997
dc.description.abstractNeurological symptoms in childhood miliary tuberculosis are generally caused by underlying tuberculous meningitis (TBM), since the 2 conditions commonly occur concurrently. Cerebral infarction, a well-recognized complication of TBM, usually results from tuberculous periarteritis and secondary thrombosis. Neuropathological studies have demonstrated that the anterior cerebral circulation is more commonly affected than the arteries of the vertebro-basilar system, and basilar artery occlusion as a presenting manifestation of childhood miliary tuberculosis or TBM has not been described before. We report a 13-month-old infant who presented with fever and convulsions, terminating in acute decerebration after a second prolonged seizure 1 week after the onset of symptoms. Magnetic resonance (MR) imaging demonstrated density changes compatible with acute vertebro-basilar ischemia as well as multiple cerebral granulomas. A chest radiograph showed diffuse miliary tuberculosis. Postmortem examination confirmed this diagnosis and revealed acute occlusion of the basilar artery by an infected (septic) thromboembolus showing granulomatous inflammation, which most likely arose from an endocardial vegetation with identical histology.
dc.description.versionArticle
dc.identifier.citationClinical Neuropathology
dc.identifier.citation16
dc.identifier.citation6
dc.identifier.issn07225091
dc.identifier.urihttp://hdl.handle.net/10019.1/13634
dc.subjectarticle
dc.subjectbasilar artery
dc.subjectbrain blood flow
dc.subjectbrain infarction
dc.subjectcase report
dc.subjectchild
dc.subjectconvulsion
dc.subjectendocarditis
dc.subjectfemale
dc.subjectfever
dc.subjectgranulomatous inflammation
dc.subjecthuman
dc.subjectmiliary tuberculosis
dc.subjectpriority journal
dc.subjectstroke
dc.subjectthromboembolism
dc.subjectvertebrobasilar insufficiency
dc.subjectCerebral Infarction
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectMagnetic Resonance Imaging
dc.subjectRhombencephalon
dc.subjectTuberculosis, Miliary
dc.titleAcute stroke in a child with miliary tuberculosis
dc.typeArticle
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