Factors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene

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dc.contributor.authorGroenewald M.
dc.contributor.authorViljoen-Bloom M.
dc.date.accessioned2011-05-15T16:01:29Z
dc.date.available2011-05-15T16:01:29Z
dc.date.issued2001
dc.description.abstractTranscription of the Schizosaccharomyces pombe malic enzyme gene, mae2, is induced when cells are grown on high glucose concentrations or under non-aerated conditions. Two cis-acting elements in the mae2 promoter, upstream activator sequences UAS1 and UAS2, are required for basal expression, whilst three negative-acting, upstream repressor sequences are involved in general derepression of mae2. Both the Pka1 and Sty1 signal transduction pathways are involved in the induced expression of mae2 under fermentative conditions. Expression of mae2 seems to be regulated in response to the carbon source, lack of oxygen and osmotic stress conditions, probably to assist in maintaining the intracellular redox balance.
dc.description.versionArticle
dc.identifier.citationCurrent Genetics
dc.identifier.citation39
dc.identifier.citation4
dc.identifier.issn1728083
dc.identifier.other10.1007/s002940100199
dc.identifier.urihttp://hdl.handle.net/10019.1/12000
dc.subjectcarbon
dc.subjectcis acting element
dc.subjectglucose
dc.subjectmalate dehydrogenase (decarboxylating)
dc.subjectoxygen
dc.subjectprotein kinase
dc.subjectaeration
dc.subjectarticle
dc.subjectcell growth
dc.subjectcontrolled study
dc.subjectculture medium
dc.subjectfermentation
dc.subjectgene expression regulation
dc.subjectgene repression
dc.subjectgene sequence
dc.subjectgenetic regulation
dc.subjectgenetic transcription
dc.subjectnonhuman
dc.subjectosmotic stress
dc.subjectoxidation reduction state
dc.subjectoxygen supply
dc.subjectpriority journal
dc.subjectpromoter region
dc.subjectSchizosaccharomyces pombe
dc.subjectsignal transduction
dc.subjectAmidohydrolases
dc.subjectBacterial Proteins
dc.subjectBase Sequence
dc.subjectBinding Sites
dc.subjectDNA Mutational Analysis
dc.subjectFermentation
dc.subjectGene Expression Regulation, Enzymologic
dc.subjectGlucose
dc.subjectMaleates
dc.subjectMolecular Sequence Data
dc.subjectOxygen
dc.subjectPromoter Regions (Genetics)
dc.subjectRNA
dc.subjectSchizosaccharomyces
dc.subjectSequence Analysis, DNA
dc.subjectSignal Transduction
dc.subjectTranscription Factors
dc.subjectTranscription, Genetic
dc.subjectSchizosaccharomyces pombe
dc.titleFactors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene
dc.typeArticle
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