Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis

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dc.contributor.authorDonald, P. R.en_ZA
dc.contributor.authorMalan, C.en_ZA
dc.date.accessioned2011-03-18T14:57:32Z
dc.date.available2011-03-18T14:57:32Z
dc.date.issued1986
dc.descriptionCITATION: Donald, P. R. & Malan, C. 1986. Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis. South African Medical Journal, 69:39-42.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractThe value of cerebrospinal fluid (CSF) lactate and lactate dehydrogenase (LD) activity in the rapid diagnosis of meningitis was investigated in three groups of patients - a 'no meningitis', an aseptic meningitis and a bacterial meningitis group. The sensitivity achieved in the detection of bacterial meningitis by CSF lactate values of 2,85 mmol/l (93,8%) and 3,9 mmol/l (89,6%) was greater than that reached by conventional chemical investigations using a CSF protein value of 1 g/l (81,5%) or a CSF glucose value of 2,2 mmol/l (68,8%) as the indicator. The sensitivity of an absolute CSF LD value of 40 U/l (86,3%) in the detection of bacterial meningitis was slightly lower than that of a CSF protein value of 1 g/l (87%) and better than the sensitivity of either a CSF/serum LD ratio of 0,1:1,0 (83,9%) or a CSF glucose level of 2,2 mmol/l (76,3%). As with conventional CSF chemistry, both investigations may give normal values in the presence of bacterial meningitis.
dc.description.versionPublisher’s version
dc.format.extent4 pages
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7478
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectMeningitisen_ZA
dc.subjectCerebrospinal fluiden_ZA
dc.titleCerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitisen_ZA
dc.typeArticle
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