Kinetic modelling in small animal imaging with PET

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dc.contributor.authorDupont P.
dc.contributor.authorWarwick J.
dc.date.accessioned2011-05-15T16:17:23Z
dc.date.available2011-05-15T16:17:23Z
dc.date.issued2009
dc.description.abstractSmall animal imaging with positron emission tomography has undergone a major evolution. This has been driven by technical improvements and the development of dedicated PET camera's for small animals. The focus has shifted from detection of tracer uptake and visualization of the tracer distribution towards the quantification of the physiological parameters necessary to use this technique for kinetic modelling of tracers. At the moment there are still several issues which need further research and evaluation before we can fully employ the possibilities of PET as an in-vivo measurement of underlying molecular biology. These issues relate to improved quantification of measurements, improved image reconstruction and processing, and the use of blood plasma data in combination with kinetic models. Besides the more technical issues, there are two more issues which need further clarification: the effect of the anaesthesia, and the effect of radiation on the experiment itself. In this review, we will give an overview of how the technique can be used but we will also discuss the issues mentioned above. The focus will be on the three major parts of the imaging procedure: acquisition, reconstruction of images, and kinetic modelling of the data. © 2009 Elsevier Inc. All rights reserved.
dc.description.versionReview
dc.identifier.citationMethods
dc.identifier.citation48
dc.identifier.citation2
dc.identifier.issn10462023
dc.identifier.other10.1016/j.ymeth.2009.03.008
dc.identifier.urihttp://hdl.handle.net/10019.1/14198
dc.subjectcobalt 57
dc.subjectfluorodeoxyglucose f 18
dc.subjectgallium 68
dc.subjectgermanium
dc.subjectraclopride c 11
dc.subjecttracer
dc.subjectanesthesia
dc.subjectblood sampling
dc.subjectcannulation
dc.subjectcomputer assisted tomography
dc.subjectdiagnostic accuracy
dc.subjectdrug distribution
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjectimage reconstruction
dc.subjectinjection
dc.subjectkinetics
dc.subjectmass spectrometry
dc.subjectmolecular dynamics
dc.subjectmolecular imaging
dc.subjectnon invasive measurement
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance imaging
dc.subjectpositron emission tomography
dc.subjectpriority journal
dc.subjectreview
dc.subjectsignal noise ratio
dc.subjectsingle photon emission computer tomography
dc.subjectAnesthesia
dc.subjectAnimals
dc.subjectDiagnostic Imaging
dc.subjectImage Processing, Computer-Assisted
dc.subjectKinetics
dc.subjectModels, Animal
dc.subjectPharmacokinetics
dc.subjectPositron-Emission Tomography
dc.subjectAnimalia
dc.titleKinetic modelling in small animal imaging with PET
dc.typeReview
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