Withdrawal of parenteral phenobarbitone : implications for resource-poor countries

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dc.contributor.authorWilmshurst, J. M.en_ZA
dc.contributor.authorVan Toorn, R.en_ZA
dc.contributor.authorNewton, C. R. J. C.en_ZA
dc.date.accessioned2011-03-18T14:56:59Z
dc.date.available2011-03-18T14:56:59Z
dc.date.issued2005
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.descriptionPlease cite as follows: Wilmshurst, J.M., Van Toorn, R. & Newton, C.R.J.C. 2005. Withdrawal of parenteral phenobarbitone : implications for resource-poor countries. South African Medical Journal, 95(6):422-423.en_ZA
dc.description.abstractParenteral phenobarbitone is an integral part of the management of status epilepticus, especially in the context of resource-poor countries. It is highly effective at controlling seizures. It is safe, cheap, can be given by rapid intravenous push or intramuscular route, boluses can be repeated, and it is recommended as part of the Advanced Paediatric Life Support guidelines. The proposed alternatives lack efficacy, practicality and/or place the child in status epilepticus at risk of respiratory compromise. The impact of the loss of parenteral phenobarbitone would be increased cardiac complications, lack of early seizure control, prolonged seizures resulting in brain damage and systemic complications. Increased numbers of patients will require artificial ventilation in centres without facilities, and centres with facilities will be unable to cope with the load of ventilated patients because of lack of safe transport systems and bed space.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extentpages 422-423
dc.identifier.citationWilmshurst, J.M., Van Toorn, R. & Newton, C.R.J.C. 2005. Withdrawal of parenteral phenobarbitone : implications for resource-poor countries. South African Medical Journal, 95(6):422-423.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7116
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectEpilepsy -- Treatmenten_ZA
dc.subjectEpilepsy -- Effect of drugs onen_ZA
dc.titleWithdrawal of parenteral phenobarbitone : implications for resource-poor countriesen_ZA
dc.typeArticleen_ZA
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