The living cell as a multi-agent organisation: A compositional organisation model of intracellular dynamics

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dc.contributor.authorJonker C.M.
dc.contributor.authorSnoep J.L.
dc.contributor.authorTreur J.
dc.contributor.authorWesterhoff H.V.
dc.contributor.authorWijngaards W.C.A.
dc.date.accessioned2011-05-15T16:02:05Z
dc.date.available2011-05-15T16:02:05Z
dc.date.issued2010
dc.description.abstractWithin the areas of Computational Organisation Theory and Artificial Intelligence, techniques have been developed to simulate and analyse dynamics within organisations in society. Usually these modelling techniques are applied to factories and to the internal organisation of their process flows, thus obtaining models of complex organisations at various levels of aggregation. The dynamics in living cells are often interpreted in terms of well-organised processes, a bacterium being considered a (micro)factory. This suggests that organisation modelling techniques may also benefit their analysis. Using the example of Escherichia coli it is shown how indeed agent-based organisational modelling techniques can be used to simulate and analyse E.coli's intracellular dynamics. Exploiting the abstraction levels entailed by this perspective, a concise model is obtained that is readily simulated and analysed at the various levels of aggregation, yet shows the cell's essential dynamic patterns. © 2010 Springer-Verlag Berlin Heidelberg.
dc.description.versionConference Paper
dc.identifier.citationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
dc.identifier.citation6220 LNCS
dc.identifier.issn3029743
dc.identifier.other10.1007/978-3-642-15034-0_10
dc.identifier.urihttp://hdl.handle.net/10019.1/12298
dc.subjectAbstraction level
dc.subjectAgent based
dc.subjectConcise model
dc.subjectEssential dynamics
dc.subjectintracellular
dc.subjectIntracellular dynamics
dc.subjectLiving cell
dc.subjectModelling techniques
dc.subjectModular control
dc.subjectMulti-Agent
dc.subjectOrganisational modeling
dc.subjectOrganisational modelling
dc.subjectProcess flows
dc.subjectRegulation and control
dc.subjectComputation theory
dc.subjectComputer simulation
dc.subjectEscherichia coli
dc.subjectIndustrial plants
dc.subjectMulti agent systems
dc.subjectSemantic Web
dc.subjectDynamics
dc.titleThe living cell as a multi-agent organisation: A compositional organisation model of intracellular dynamics
dc.typeConference Paper
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