Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor
Date
2021-06
Journal Title
Journal ISSN
Volume Title
Publisher
Nature
Abstract
Gastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rating scale (GSRS) was completed by 76 participants at baseline and at 6 months. GIS frequency was defined as having at least one symptom (GSRS > 1). Severity was indicated by the GSRS score. Transplant candidates: GIS frequency was 88.9% and 86.3% at baseline and 6 months respectively. Indigestion was the most frequent (79.6% and 66.7% at baseline and 6 months), and severe GIS (GSRS 2.3). Women reported global mean (p = 0.030) severity significantly more than men. Transplant recipients: GIS frequency was 95.2% and 76.2% at baseline and 6 months respectively. At both assessment points, indigestion occurred most frequently (85.7% and 61.9% respectively). Highest GSRS was reported for indigestion at baseline (2.33) and at 6 months (1.33). Waist circumference (WC) was positively associated with the severity of constipation GSRS. GIS are common in both groups, especially indigestions. WC in transplant recipients should be monitored.
Description
CITATION: Martin, C. J. et al. 2021. Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor. Scientific Reports, 11:12592, doi:10.1038/s41598-021-92016-2.
The original publication is available at https://www.nature.com
The original publication is available at https://www.nature.com
Keywords
Kidneys -- Transplantation, Gastrointestinal system -- Diseases, Organ donors, HIV-positive persons
Citation
Martin, C. J. et al. 2021. Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor. Scientific Reports, 11:12592, doi:10.1038/s41598-021-92016-2.