Effects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration

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dc.contributor.authorTheron C.N.
dc.contributor.authorDe Villiers A.S.
dc.contributor.authorTaljaard J.J.F.
dc.contributor.authorTheron C.N.
dc.contributor.authorDe Villiers A.S.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:26Z
dc.date.accessioned2011-05-15T16:17:26Z
dc.date.available2011-05-15T16:17:26Z
dc.date.available2011-05-15T16:17:26Z
dc.date.issued1993
dc.date.issued1993
dc.description.abstractEffects of DSP-4 on noradrenaline (NA), 3-methoxy-4-hydroxyphenyl glycol (MHPG), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels and on beta adrenoceptor binding kinetic (Bmax and K(D)) in rat hippocampus, cortex and hypothalamus were studied between 24 hours and 14 days after systemic administration. Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4. No significant changes in K(D) value were observed in hypothalamus, but significant increases in this parameter were measured in hippocampus and cortex. NA and MHPG levels were significantly decreased in all three brain regions, but MHPG/NA ratios were increased in hippocampus, decreased in cortex and unchange in hypothalamus. Very prominent increases in 5-HIAA levels were observed in all three brain regions, but only at one day after DSP-4. The greatest increases in 5-HIAA levels occurred in the hippocampus, but this effect of DPS-4 appeared to be slightly diminished by pre-treatment with fluoxetine. In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
dc.description.abstractEffects of DSP-4 on noradrenaline (NA), 3-methoxy-4-hydroxyphenyl glycol (MHPG), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels and on beta adrenoceptor binding kinetic (Bmax and K(D)) in rat hippocampus, cortex and hypothalamus were studied between 24 hours and 14 days after systemic administration. Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4. No significant changes in K(D) value were observed in hypothalamus, but significant increases in this parameter were measured in hippocampus and cortex. NA and MHPG levels were significantly decreased in all three brain regions, but MHPG/NA ratios were increased in hippocampus, decreased in cortex and unchange in hypothalamus. Very prominent increases in 5-HIAA levels were observed in all three brain regions, but only at one day after DSP-4. The greatest increases in 5-HIAA levels occurred in the hippocampus, but this effect of DPS-4 appeared to be slightly diminished by pre-treatment with fluoxetine. In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
dc.description.versionArticle
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation18
dc.identifier.citation12
dc.identifier.citationNeurochemical Research
dc.identifier.citation18
dc.identifier.citation12
dc.identifier.issn03643190
dc.identifier.issn03643190
dc.identifier.other10.1007/BF00975054
dc.identifier.other10.1007/BF00975054
dc.identifier.urihttp://hdl.handle.net/10019.1/14215
dc.identifier.urihttp://hdl.handle.net/10019.1/14215
dc.subjectbeta adrenergic receptor; monoamine; noradrenalin; serotonin; animal experiment; animal tissue; article; binding kinetics; brain cortex; hippocampus; hypothalamus; male; neurochemistry; nonhuman; priority journal; rat; receptor binding; Animal; Benzylamines; Biogenic Monoamines; Brain; Cerebral Cortex; Hippocampus; Hydroxyindoleacetic Acid; Hypothalamus; Kinetics; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Serotonin; Support, Non-U.S. Gov't; Animalia
dc.subjectbeta adrenergic receptor
dc.subjectmonoamine
dc.subjectnoradrenalin
dc.subjectserotonin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbinding kinetics
dc.subjectbrain cortex
dc.subjecthippocampus
dc.subjecthypothalamus
dc.subjectmale
dc.subjectneurochemistry
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectreceptor binding
dc.subjectAnimal
dc.subjectBenzylamines
dc.subjectBiogenic Monoamines
dc.subjectBrain
dc.subjectCerebral Cortex
dc.subjectHippocampus
dc.subjectHydroxyindoleacetic Acid
dc.subjectHypothalamus
dc.subjectKinetics
dc.subjectMale
dc.subjectMethoxyhydroxyphenylglycol
dc.subjectNorepinephrine
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Adrenergic, beta
dc.subjectSerotonin
dc.subjectSupport, Non-U.S. Gov't
dc.subjectAnimalia
dc.titleEffects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration
dc.titleEffects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration
dc.typeArticle
dc.typeArticle
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