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Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa

dc.contributor.authorVan Schalkwyk, Carien_ZA
dc.contributor.authorVariava, Ebrahimen_ZA
dc.contributor.authorShapiro, Adrienne E.en_ZA
dc.contributor.authorRakgokong, Modiehien_ZA
dc.contributor.authorMasonoke, Katlegoen_ZA
dc.contributor.authorLebina, Limakatsoen_ZA
dc.contributor.authorWelte, Alexen_ZA
dc.contributor.authorMartinson, Neilen_ZA
dc.date.accessioned2016-03-09T06:16:16Z
dc.date.available2016-03-09T06:16:16Z
dc.date.issued2014-04
dc.identifier.citationVan Schalkwyk, C. et al. 2014. Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. PLoS ONE, 9(4):e95372, doi:10.1371/journal.pone.0095372.
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0095372
dc.identifier.urihttp://hdl.handle.net/10019.1/98264
dc.descriptionCITATION: Van Schalkwyk, C. et al. 2014. Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. PLoS ONE, 9(4):e95372, doi:10.1371/journal.pone.0095372.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractObjective: To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB. Design: A prospective cohort study in the Matlosana sub-district of North West Province, South Africa. Methods: Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined. Results: For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9–1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9–9.0/100py) and 0.7/100py (95% CI 0.3–1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3–8.4/100py). Conclusions: In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.en_ZA
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095372
dc.format.extent6 pages
dc.language.isoen_ZAen_ZA
dc.publisherPLoS
dc.subjectTuberculosis -- South Africa -- North Westen_ZA
dc.subjectHIV infections -- South Africa -- North Westen_ZA
dc.titleIncidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africaen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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