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Chronic prosopis glandulosa treatment blunts neutrophil infiltration and enhances muscle repair after contusion injury

dc.contributor.authorGeorge, Cindyen_ZA
dc.contributor.authorSmith, Carineen_ZA
dc.contributor.authorIsaacs, Ashwin W.en_ZA
dc.contributor.authorHuisamen, Barbaraen_ZA
dc.date.accessioned2015-07-24T09:14:47Z
dc.date.available2015-07-24T09:14:47Z
dc.date.issued2015-01
dc.identifier.citationGeorge, C., et al. 2015. Chronic prosopis glandulosa treatment blunts neutrophil infiltration and enhances muscle repair after contusion injury. Nutrients, 7(2):815-830, doi:10.3390/nu7020815
dc.identifier.issn2072-6643 (online)
dc.identifier.otherdoi:10.3390/nu7020815
dc.identifier.urihttp://hdl.handle.net/10019.1/97302
dc.descriptionCITATION: George, C., et al. 2015. Chronic prosopis glandulosa treatment blunts neutrophil infiltration and enhances muscle repair after contusion injury. Nutrients, 7(2):815-830, doi:10.3390/nu7020815.
dc.descriptionThe original publication is available at https://www.mdpi.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.
dc.description.abstractThe current treatment options for soft tissue injuries remain suboptimal and often result in delayed/incomplete recovery of damaged muscle. The current study aimed to evaluate the effects of oral Prosopis glandulosa treatment on inflammation and regeneration in skeletal muscle after contusion injury, in comparison to a conventional treatment. The gastrocnemius muscle of rats was subjected to mass-drop injury and muscle samples collected after 1-, 3 h, 1- and 7 days post-injury. Rats were treated with P. glandulosa (100 mg/kg/day) either for 8 weeks prior to injury (up until day 7 post-injury), only post-injury, or with topically applied diclofenac post-injury (0.57 mg/kg). Neutrophil (His48-positive) and macrophage (F4/80-positive) infiltration was assessed by means of immunohistochemistry. Indicators of muscle satellite cell proliferation (ADAM12) and regeneration (desmin) were used to evaluate muscle repair. Chronic P. glandulosa and diclofenac treatment (p < 0.0001) was associated with suppression of the neutrophil response to contusion injury, however only chronic P. glandulosa treatment facilitated more effective muscle recovery (increased ADAM12 (p < 0.05) and desmin (p < 0.001) expression), while diclofenac treatment had inhibitory effects on repair, despite effective inhibition of neutrophil response. Data indicates that P. glandulosa treatment results in more effective muscle repair after contusion.en_ZA
dc.description.urihttp://www.mdpi.com/2072-6643/7/2/815en_ZA
dc.format.extent16 pagesen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.subjectFabaceaeen_ZA
dc.subjectInflammation -- Treatmenten_ZA
dc.subjectMass-drop injuryen_ZA
dc.subjectNonsteroidal anti-inflammatory agentsen_ZA
dc.subjectMusculoskeletal system -- Regenerationen_ZA
dc.titleChronic prosopis glandulosa treatment blunts neutrophil infiltration and enhances muscle repair after contusion injuryen_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthor retains copyright


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