Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism
Date
2014-03
Authors
Doruyter, Alexander G.
Hartley, Tharbit
Ameyo, Jonathan W.
Davids, M. R.
Warwick, James M.
Journal Title
Journal ISSN
Volume Title
Publisher
Lippincott, Williams & Wilkins
Abstract
Background Preoperative localization of parathyroid
lesions is potentially beneficial in renal patients with
hyperparathyroidism. The aim of this study was to
determine the localizing value of hybrid single-photon
emission computed tomography combined with low-dose
x-ray computed tomography (SPECT/LDCT) compared with
SPECT alone and whether the LDCT improved reader
confidence. Patients and methods A retrospective study examined
parathyroid scintigraphy results of patients previously
referred with a diagnosis of renal hyperparathyroidism. All
patients underwent planar scintigraphy using technetium-
99m (99mTc)-pertechnetate, which was immediately
followed with 99mTc-sestamibi and SPECT/LDCT ∼ 60 min
after sestamibi injection and a delayed static image to
assess differential washout. Planar subtraction images
were generated. Two nuclear physicians, assisted by a
radiologist, reported on planar+SPECT images followed by
planar+SPECT/LDCT images.
Results Thirty-seven patients (males: 21; females: 16)
were included (mean age 39 years, range: 23.9–55.5). Mean
creatinine level was 878 μmol/l (109–1839), mean corrected
calcium level was 2.42 mmol/l (1.77–3.64), and median
parathyroid hormone level was 156.2 pmol/l (2.4 to >201).
Twenty-three patients had positive planar and SPECT
Description
Doruyter, A.G. et al. 2014. Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism. Nuclear Medicine Communications, 35(8):884-889, doi:10.1097/MNM.0000000000000131.
The original publication is available at http://journals.lww.com/nuclearmedicinecomm/pages/default.aspx
For the university, the copy is available via the OVID platform
The original publication is available at http://journals.lww.com/nuclearmedicinecomm/pages/default.aspx
For the university, the copy is available via the OVID platform
Keywords
Parathyroid glands -- Imaging, Single-photon emission computed tomography, Parathyroid glands -- Tomography
Citation
Doruyter, A.G. et al. 2014. Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism. Nuclear Medicine Communications, 35(8):884-889, doi:10.1097/MNM.0000000000000131.