An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the Western Cape, South Africa

Johnson R. ; Warren R. ; Strauss O.J. ; Jordaan A.M. ; Falmer A.A. ; Beyers N. ; Schaaf H.S. ; Murray M. ; Cloete K. ; Van Helden P.D. ; Victor T.C. (2006)

Article

During October 2005, four children in a school in Cape Town were identified with multidrug-resistant tuberculosis (MDR-TB). Genetic analysis confirmed that these isolates belonged to a single cluster (Beijing cluster 220) and that all harboured a -15 inhAC-T promoter mutation demonstrating transmission. Genetic analysis of isolates cultured from patients from the Boland-Overberg-South Cape-Karoo and Cape Town regions showed that 28% (58/209) of patients infected with a Beijing strain had the cluster 220 genotypes and that all harboured the same -15 inhAC-T promoter mutation. The presence of these transmissible MDR-TB strains may pose a threat to the community, and rigorous infection control measures are needed to ensure the safety of those exposed. © 2006 The Union.

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