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Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses

dc.contributor.authorAyepola, Omolola R.
dc.contributor.authorChegou, Novel N.
dc.contributor.authorBrooks, Nicole L.
dc.contributor.authorOguntibeju, Oluwafemi O.
dc.date.accessioned2014-02-07T08:20:04Z
dc.date.available2014-02-07T08:20:04Z
dc.date.issued2013-12
dc.identifier.citationAyepola, O. R., Chegou, N. N., Brooks, N. L. & Oguntibeju, O. O. 2013. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complementary and Alternative Medicine, 13(1):363, doi:10.1186/1472-6882-13-363.en_ZA
dc.identifier.issn1472-6882 (online)
dc.identifier.otherdoi:10.1186/1472-6882-13-363
dc.identifier.urihttp://hdl.handle.net/10019.1/86116
dc.descriptionPlease cite as follows:en_ZA
dc.descriptionAyepola, O. R., Chegou, N. N., Brooks, N. L. & Oguntibeju, O. O. 2013. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complementary and Alternative Medicine, 13(1):363, doi:10.1186/1472-6882-13-363.
dc.descriptionThe original publication is available at http://www.biomedcentral.com/1472-6882/13/363
dc.description.abstractBackground: Chronic inflammation plays a crucial role in hyperglycemia-induced liver injury. Kolaviron (KV), a natural biflavonoid from Garcinia kola seeds have been shown to possess anti- inflammatory properties which has not been explored in diabetes. To our knowledge, this is the first study to investigate the effect of KV on pro-inflammatory proteins in the liver of diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg) in male Wistar rats. Kolaviron (100 mg/kg) was administered orally five times a week for six weeks. The concentrations of cytokines and chemokine were measured using Bio-plex Pro™ magnetic bead-based assays (Bio-Rad Laboratories, Hercules, USA). Plasma glucose and serum biomarkers of liver dysfunction were analyzed with diagnostic kits in an automated clinical chemistry analyzer. Insulin concentration was estimated by radioimmunoassay (RIA). Result: Kolaviron (100mg/kg) treatment significantly ameliorated hyperglycemia and liver dysfunction. Serum levels of hepatic marker enzymes were significantly reduced in kolaviron treated diabetic rats. Kolaviron prevented diabetes induced increase in the hepatic levels of proinflammatory cytokines; interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF-α) and monocyte chemotactic protein (MCP-1). Conclusion: The results of this study demonstrate that the hepatoprotective effects of kolaviron in diabetic rats may be partly associated with its modulating effect on inflammatory responses.en_ZA
dc.description.sponsorshipThe study was supported by the University Research Fund (URF) of the Cape Peninsula University of Technology
dc.description.sponsorshipThe National Research Foundation, South Africa (NRF)en_ZA
dc.format.extent9 p. : ill., black and white
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.subjectDiabetes -- Complicationsen_ZA
dc.subjectChronic inflammation -- Complicationsen_ZA
dc.subjectLiver diseases -- Preventionen_ZA
dc.subjectKolavironen_ZA
dc.subjectAnimal experimentationen_ZA
dc.subjectHyperglycemia-induced liver injury -- Effect of chronic inflammation onen_ZA
dc.titleKolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responsesen_ZA
dc.typeArticleen_ZA
dc.date.updated2013-12-23T16:04:40Z
dc.description.versionPublishers' Versionen_ZA
dc.language.rfc3066en
dc.rights.holderOmolola R Ayepola et al.; licensee BioMed Central Ltd.en_ZA


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