Prostaglandin effects in the neuroendocrine mammalian brain

Macfarlane C. M. ; Taljaard J. J. F. (1985)

Publishers' version

The original publication is available at http://www.samj.org.za

Article

Various prostaglandins (PGs) have been found in several areas of the brain. PGs of the E series have been found in the pituitary and pineal glands and the median eminence, and they have been shown to influence hypothalamic endocrine-release characteristics and release of melatonin from the pineal gland. It has been suggested that they may act, along with membrane phospholipids, as a link between neuronal depolarization, calcium uptake and neurotransmitter release. They may also influence postsynaptic effects of neurotransmitters. These latter effects may be due to interaction with membrane phospholipid- and cyclic nucleotide-induced changes of specific protein kinases. The PGs may act as intracellular mediators of neuro-endocrine control.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/8002
This item appears in the following collections: