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Cardiac involvement in mixed connective tissue disease : a fatal case of scleroderma combined with systemic lupus erythematosus

dc.contributor.authorPrzybojewski, J. Z.
dc.contributor.authorMynhardt, J. H.
dc.contributor.authorVan der Walt, J. J.
dc.contributor.authorTiedt, F. A. C.
dc.date.accessioned2011-03-18T14:59:42Z
dc.date.available2011-03-18T14:59:42Z
dc.date.issued1985-10
dc.identifier.citationPrzybojewski, J. Z., Mynhardt, J. H., Van Der Walt, J. J. & Tiedt, F. A. C. 1985. Cardiac involvement in mixed connective tissue disease. A fatal case of scleroderma combined with systemic lupus erythematosus. South African Medical Journal, 68(9):680-686.
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7996
dc.descriptionThe original publication is available at http://archive.samj.org.za/
dc.description.abstractA 27-year-old black woman with cardiac failure, angina pectoris and Raynaud's syndrome is presented. Skin biopsy and barium studies established the diagnosis of scleroderma (progressive systemic sclerosis (PSS)). Systemic lupus erythematosus (SLE) was strongly suggested by the results of immunological studies and increasing severity of renal failure. Because of the possibility of a cardiomyopathy, cardiac catheterization, selective coronary angiography and right ventricular endomyocardial biopsy were carried out but failed to show any histological features of either SLE or PSS. The patient went into progressive renal failure despite immunosuppressive therapy and plasmapheresis and died; consent for autopsy was refused. A final diagnosis of mixed connective tissue disease (MCTD) was made. The salient features of cardiac involvement in SLE, PSS and MCTD are outlined.
dc.format.extent7 p. : ill.
dc.language.isoen_ZA
dc.publisherHealth and Medical Publishing Group (HMPG)
dc.subjectSystemic sclerodermaen_ZA
dc.subjectConnective tissues -- Diseasesen_ZA
dc.titleCardiac involvement in mixed connective tissue disease : a fatal case of scleroderma combined with systemic lupus erythematosusen_ZA
dc.typeArticle
dc.description.versionPublishers' Version
dc.rights.holderAuthors retain copyright


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