Aetiology of pulmonary dysfunction in total hip replacement operations: The influence of nifedipine on the factors involved
The original publication is available at http://www.samj.org.za
Patients undergoing total hip replacement surgery who developed pulmonary dysfunction (PD) demonstrated evidence of a complement activation and increased thromboxane A2 (TXA2) synthesis. In a double-blind study nifedipine (Adalat; Bayer-Miles) was shown to inhibit complement activation and TXA2 synthesis and thus appears to offer protection against PD.
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