Aetiology of pulmonary dysfunction in total hip replacement operations: The influence of nifedipine on the factors involved

Du Toit H.J. ; Macfarlane C.M. ; Taljaard J.J.F. (1987)


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Patients undergoing total hip replacement surgery who developed pulmonary dysfunction (PD) demonstrated evidence of a complement activation and increased thromboxane A2 (TXA2) synthesis. In a double-blind study nifedipine (Adalat; Bayer-Miles) was shown to inhibit complement activation and TXA2 synthesis and thus appears to offer protection against PD.

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