Aetiology of pulmonary dysfunction in total hip replacement operations: The influence of nifedipine on the factors involved

Du Toit, H. J. ; Macfarlane, C. M. ; Taljaard, J. J. F. ; King, J. B. ; Cooper, R. C. (1987-05)

CITATION: Du Toit, H.J. et al. 1987. Aetiology of pulmonary dysfunction in total hip replacement operations: The influence of nifedipine on the factors involved. S Afr Med J, 71(5):279-282.

The original publication is available at http://www.samj.org.za

Article

ENGLISH ABSTRACT: Patients undergoing total hip replacement surgery who developed pulmonary dysfunction (PD) demonstrated evidence of a complement activation and increased thromboxane A2 (TXA2) synthesis. In a double-blind study nifedipine (Adalat; Bayer-Miles) was shown to inhibit complement activation and TXA2 synthesis and thus appears to offer protection against PD.

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