Epstein-Barr virus reactivation in renal transplant recipients

Hallett, A. F. ; Bestbier, A. ; Ford, B. M. ; Mohrcken, S. I. (1987-3)

CITATION: Hallett, A.F. et al. 1987. Epstein-Barr virus reactivation in renal transplant recipients. S Afr Med J, 71(6):347-351.

The original publication is available at http://www.samj.org.za


Renal transplant recipients at Tygerberg Hospital were investigated to determine the importance of Epstein-Barr virus (EBV) as a pathogen in these patients. All 106 patients investigated were shown to have EBV antibodies before transplantation and most had serological evidence of reactivation of the infection after transplantation. A mild clinical illness was present in a few patients concomitant with EBV reactivation, which may suggest that this virus has a role in the morbidity of some renal transplant recipients. Lymphoblastoid cell lines were established from 11 renal transplant recipients; 5 of these cell lines were shown to be virus producers and 1 is thought to have unique properties.

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