Biological effect of asbestos dust on the peritoneal viscera of rats

Engelbrecht F.M. ; Burger B.F. (1973)


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Crocidolite and chrysotile asbestos suspensions were ip injected into rats. Peritoneal mesotheliomas were induced in 90% of the crocidolite group and in 30% of the chrysotile group. The pathology and possible pathogenesis are described and discussed. It is postulated that the asbestos fibers are encapsulated by fibrous tissue and that a soluble carcinogen then diffuses from these fibers to the mesothelial cells, causing anaplastic changes.

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