Urinary porphyrins and porphyrin precursors in normal pregnancy. Relationship to urinary total oestrogen excretion
De Klerk, M.
Shanley, B. C.
MetadataShow full item record
Please cite this item using this persistent URLhttp://hdl.handle.net/10019.1/7742
This item appears in the following collection/s
The relationship between urinary excretion of porphyrins, porphyrin precursors and total oestrogens in normal pregnancy was investigated. Significant increases in total oestrogen, delta aminolaevulinic acid (ALA) and coproporphyrin (COPRO) excretion were noted. However, no close correlation was found between total oestrogen excretion and urinary output of ALA and COPRO. The results suggest that the observed increases in ALA and COPRO excretion during pregnancy may not simply be the result of steroid mediated induction of hepatic haem biosynthesis, as has been proposed.