Leukaemogenesis in Down's syndrome
CITATION: Gericke, G. S., et al. 1977. Leukaemogenesis in Down's syndrome. South African Medical Journal, 51(6):158-162.
The original publication is available at http://www.samj.org.za
Due to the fixed karotype and documented malignancy risk in patients with Down's syndrome, recently described aetiological factors can be assigned to their proper places in a conceptual framework for leukaemogenesis in these individuals. This is a more profitable approach than those in which various types of karyotypic patterns are matched to different malignancies. It seems that viruses may play a special role, but they need interaction with other factors, most of which are present in Down's syndrome. A unifying concept which may be helpful in establishing research priorities is presented.