Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer

Albrecht, C.F. ; Theron, E.L. ; Albrecht, C.F. ; Theron, E.L. (1988)

Article

The original publication is available at http://www.samj.org.za

Recent molecular genetic experiments conducted in the USA and The Netherlands have isolated specific mutations in human lung cancer cells. These data implicate the activation of the K-ras oncogene in the pathogenesis of adenocarcinoma of the lungs of heavy smokers and the deletion of DNA from the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung. The implications of these results are discussed and explained in the light of current DNA-manipulative technology which is now available in RSA.

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