Research Articles (Nephrology)
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Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa
(African Association of Nephrology, 2020)ENGLISH ABSTRACT: Africa trails the rest of the world in COVID-19 cases and deaths. However, as the pandemic spreads through the continent, we expect increases in community infection in the months ahead. Patients with ... -
Pattern of renal amyloidosis in South Africa
(BMC (part of Springer Nature), 2019)Background: Kidney disease is a serious manifestation of systemic amyloidosis and a major cause of morbidity and mortality. Tuberculosis (TB) occurs up to 27 times more commonly in human immunodeficiency virus (HIV) ... -
Human resources for nephrology in South Africa : a mixed-methods study
(Public Library of Science, 2020-02-13)Introduction: The global nephrology workforce is shrinking and, in many countries, is unable to meet healthcare needs. Accurate data pertaining to human resources in nephrology in South Africa is lacking. This data is ... -
Sporotrichosis in renal transplant patients : two case reports and a review of the literature
(BMC (part of Springer Nature), 2020-06-26)Introduction: Sporotrichosis is a rare fungal infection in transplant patients; among these patients, it occurs mostly in renal transplant patients. Sporothrix schenkii is the primary pathogen responsible. A high index ... -
Pseudohypokalaemia and pseudohypoxaemia in a patient with acute myeloid leukaemia
(African Association of Nephrology, 2020)ENGLISH ABSTRACT: Spurious laboratory results are frequently encountered in patients with haematological disorders and lead to unnecessary additional laboratory investigations and inappropriate treatment. An 80-year-old ... -
Renal denervation : mechanisms and clinical aspects
(African Association of Nephrology, 2020)ENGLISH ABSTRACT: Hypertension is a global health issue of paramount importance, which has not spared the African continent where an unacceptably high prevalence of uncontrolled blood pressure prevails among its population. ... -
Pattern of renal amyloidosis in South Africa
(BMC (part of Springer Nature), 2019-11-09)Background: Kidney disease is a serious manifestation of systemic amyloidosis and a major cause of morbidity and mortality. Tuberculosis (TB) occurs up to 27 times more commonly in human immunodeficiency virus (HIV) ... -
Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease
(BMC (part of Springer Nature), 2019-10-29)Background: Preliminary studies have shown the potential use of salivary creatinine concentration in the diagnosis of chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, studies must be done ... -
Calcific uraemic arteriolopathy (calciphylaxis) in patients on renal replacement therapy
(Health and Medical Publishing Group, 2017)Background. Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage ... -
Hypernatraemia in South African hospitalized patients
(African Association of Nephrology, 2019)Background: Hypernatraemia is a common electrolyte problem in hospitalized patients and is associated with a high mortality rate. We determined the incidence, causes, management, and outcomes of hypernatraemia in ... -
Prevalence of chronic kidney disease and association with cardiovascular risk factors among teachers in Cape Town, South Africa
(Oxford University Press, 2017)Background: There is a need to determine the feasibility of conducting studies of chronic diseases among large cohorts of African patients. One aim of the South African feasibility study was to determine the prevalence ... -
Hypodipsic-hypernatremia syndrome in an adult with polycythemia : a case report
(BMC (part of Springer Nature), 2018-12-27)Background: Hypernatremia is a very common electrolyte disorder and is frequently encountered in out-patient as well as in-hospital settings. We describe an adult who was found to have unexplained relative polycythemia ... -
Residual renal function in chronic dialysis is not associated with reduced erythropoietin-stimulating agent dose requirements : a cross-sectional study
(BioMed Central, 2017-11-25)Background: Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is ... -
Strengthening renal registries and ESRD research in Africa
(Elsevier, 2017)ENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic ... -
An effective approach to chronic kidney disease in South Africa
(Health & Medical Publishing Group, 2016)ENGLISH ABSTRACT: Very few patients with end-stage kidney disease in South Africa receive renal replacement treatment (RRT), despite the rapidly growing demand, because of resource constraints. Nephrologists who agonise ... -
Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy
(Oxford University Press European Renal Association, 2016-06-19)Background: Intradialytic hypertension (IDH) increases morbidity and mortality. The prevalence in South Africa is unknown. The pathogenesis is unclear, but it has been suggested that IDH may be due to subclinical fluid ... -
A renal registry for Africa : first steps
(Oxford University Press European Renal Association, 2016)ENGLISH ABSTRACT: There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African ... -
Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings
(BioMed Central, 2017-01-26)Background Gitelman syndrome (GS) is an autosomal recessive renal tubular disorder characterised by renal salt wasting with hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria. It is caused by mutations ... -
Quality of life in patients on chronic dialysis in South Africa : a comparative mixed methods study
(BioMed Central, 2017-01-05)Background: The increasing prevalence of treated end-stage renal disease and low transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be aimed at prolonging lives but also improve ... -
Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans
(BioMed Central, 2015-07-04)Background: Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean ...
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