Research Articles (Nephrology)

 

Recent Submissions

  • Strengthening renal registries and ESRD research in Africa 

    Davids, M. Razeen; Caskey, Fergus J.; Young, Taryn; Balbir Singh, Gillian K. (Elsevier, 2017)
    ENGLISH ABSTRACT: In Africa the combination of non-communicable diseases, infectious diseases, exposure to environmental toxins and acute kidney injury related to trauma and childbirth are driving an epidemic of chronic ...

  • An effective approach to chronic kidney disease in South Africa 

    Moosa, Mohammed Rafique; Meyers, Anthony M.; Gottlich, Errol; Naicker, Sarala (Health & Medical Publishing Group, 2016)
    ENGLISH ABSTRACT: Very few patients with end-stage kidney disease in South Africa receive renal replacement treatment (RRT), despite the rapidly growing demand, because of resource constraints. Nephrologists who agonise ...

  • A renal registry for Africa : first steps 

    Davids, M. Razeen; Eastwood, John B.; Selwood, Neville H.; Arogundade, Fatiu A.; Ashuntantang, Gloria; Gharbi, Mohammed Benghanem; Jarraya, Faical; MacPhee, Iain A. M.; McCulloch, Mignon; Plange-Rhule, Jacob; Swanepoel, Charles R.; Adu, Dwomoa (Oxford University Press European Renal Association, 2016)
    ENGLISH ABSTRACT: There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national renal registries have been established but have not been sustainable because of resource limitations. The African ...

  • Gitelman syndrome in a South African family presenting with hypokalaemia and unusual food cravings 

    Van der Merwe, Pieter Du Toit; Rensburg, Megan A.; Haylett, William L.; Bardien, Soraya; Davids, M. Razeen (BioMed Central, 2017-01-26)
    Background Gitelman syndrome (GS) is an autosomal recessive renal tubular disorder characterised by renal salt wasting with hypokalaemia, metabolic alkalosis, hypomagnesaemia and hypocalciuria. It is caused by mutations ...

  • Quality of life in patients on chronic dialysis in South Africa : a comparative mixed methods study 

    Tannor, Elliot K.; Archer, Elize; Kapembwa, Kenneth; Van Schalkwyk, Susan C.; Davids, M. Razeen (BioMed Central, 2017-01-05)
    Background: The increasing prevalence of treated end-stage renal disease and low transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be aimed at prolonging lives but also improve ...

  • Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans 

    Mogueo, Amelie; Echouffo-Tcheugui, Justin B.; Matsha, Tandi E.; Erasmus, Rajiv T.; Kengne, Andre P. (BioMed Central, 2015-07-04)
    Background: Chronic kidney disease (CKD) is a global challenge. Risk models to predict prevalent undiagnosed CKD have been published. However, none was developed or validated in an African population. We validated the Korean ...

  • Use of the accountability for reasonableness approach to improve fairness in accessing dialysis in a middle- income country 

    Moosa, Mohammed Rafique; Maree, Jonathan David; Chirehwa, Maxwell T.; Benatar, Solomon R. (Public Library of Science, 2016)
    Universal access to renal replacement therapy is beyond the economic capability of most low and middle-income countries due to large patient numbers and the high recurrent cost of treating end stage kidney disease. In ...

  • Important causes of chronic kidney disease in South Africa 

    Moosa, M. R.; Van Der Walt, I.; Naicker, S.; Meyers, A. M. (Health & Medical Publishing Group, 2015)
    In hypertensive patients without chronic kidney disease (CKD) the goal is to keep blood pressure (BP) at ≤140/90 mmHg. When CKD is present, especially where there is proteinuria of ≥0.5 g/day, the goal is a BP of ≤130/80 ...

  • Bolus administration of intravenous glucose in the treatment of hyperkalemia : a randomized controlled trial 

    Chothia, Mogamat-Yazied; Halperin, Mitchell L.; Rensburg, Megan A.; Hassan, Mogamat Shafick; Davids, Mogamat Razeen (Karger, 2014-02)
    Background: Hyperkalemia is a common medical emergency that may result in serious cardiac arrhythmias. Standard therapy with insulin plus glucose reliably lowers the serum potassium concentration ([K + ]) but carries ...

  • Effect of improving the usability of an e-learning resource : a randomized trial 

    Davids, Mogamat Razeen; Chikte, Usuf M. E.; Halperin, Mitchell L. (HighWire, 2014-06)
    Optimizing the usability of e-learning materials is necessary to reduce extraneous cognitive load and maximize their potential educational impact. However, this is often neglected, especially when time and other resources ...

  • Usability testing of a multimedia e-learning resource for electrolyte and acid-base disorders 

    Davids, MR; Chikte, Usuf; Grimmer-Somers, Karen; Halperin, Mitchell L. (Wiley Online Open, 2013-04)
    The usability of computer interfaces may have a major influence on learning. Design approaches that optimize usability are commonplace in the software development industry but are seldom used in the development of e-learning ...

  • Development and evaluation of a multimedia e-learning resource for electrolyte and acid-base disorders 

    Davids, MR; Chikte, Usuf M. E.; Halperin, Mitchell L. (American Physiological Society, 2011-10)
    This article reports on the development and evaluation of a Web-based application that provides instruction and hands-on practice in managing electrolyte and acid-base disorders. Our teaching approach, which focuses on ...

  • The role of the endothelium in the reduction of restenosis following balloon angioplasty 

    Davids, MR; Page, C.; Muller, C. J.; Rossouw, D. J.; Doubell, A. F. (Clinics Cardive Publishing, 1998-10)
    Objective. Coronary angioplasty is complicated in one-third of cases by restenosis due to intimal hyperplasia. This is the result of the migration and proliferation of vascular smooth-muscle cells (SMCs) and correlates ...

  • Misuse of blood 

    Burman, N. D. (HMPG, 1977-11)
    LETTER: In recent months an increasing number of patients have been referred to us by doctors from outside with a standard note: "... breathlessness ... tiredness ... anaemia (4-8 g/100 ml) ... blood transfusion given ... ...

  • Impact of age, gender and race on patient and graft survival following renal transplantation - developing country experience 

    Moosa, M. Rafique (Health & Medical Publishing Group, 2003)
    Background. Optimising renal allograft survival is crucially important in developing countries because of limited resources to treat irreversible renal failure. However, although many factors can be manipulated to improve ...

  • An audit of 24-hour creatinine clearance measurements at Tygerberg Hospital and comparison with prediction equations 

    Le Riche, Mia; Zemlin, Annalise E.; Erasmus, Rajiv T.; Davids, MR (Health and Medical Publishing Group (HMPG), 2007-10)
    BACKGROUND: Internationally, clinical guidelines recommend the use of creatinine-based equations to estimate glomerular filtration rate (GFR) for assessment and follow-up of kidney disease. The routine use of 24-hour ...