Pharmacological challenge with a serotonin 1D agonist in alcohol dependence

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dc.contributor.author Vythilingum, Bavanisha
dc.contributor.author Hugo, Charmaine J.
dc.contributor.author Maritz, J. Stefan
dc.contributor.author Pienaar, Willie P.
dc.contributor.author Stein, Dan J.
dc.date.accessioned 2010-12-15T07:23:25Z
dc.date.available 2010-12-15T07:23:25Z
dc.date.issued 2005-08
dc.identifier.citation Vythilingum, B, Hugo, CJ, Maritz, JS, Pienaar, W & Stein, DJ 2005, 'Pharmacological challenge with a serotonin 1D agonist in alcohol dependence', BMC Psychiatry, 5(1):31. en_ZA
dc.identifier.issn 1471-244X
dc.identifier.other http://dx.doi.org/10.1186/1471-244X-5-31
dc.identifier.uri http://hdl.handle.net/10019.1/5128
dc.description.abstract Background: Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low serotonin promotes alcohol seeking behavior. Sumatriptan is a serotonin 1D agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink. Methods: Fifteen patients with alcohol dependence who had undergone detoxification were recruited. Sumatriptan (100 mg) and placebo was administered in cross-over fashion on 2 separate days 72 hours apart. Both patients and raters were blind to all treatments. Patients were assessed on the following scales at -30, 0, 30, 90, 150 and 210 minutes: A 6-item scale designed to rate the patient's intention to drink; The Sensation Scale; a 13-item affect analog scale designed to rate the pattern and extent of emotional changes; and an 8-item scale designed to rate the patient's craving for alcohol Results: No significant differences were found between the placebo and sumatriptan groups and no significant cross over effects were found. Conclusion: The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism. en_ZA
dc.format.extent 5 p.
dc.language.iso en_ZA en_ZA
dc.publisher BioMed Central en_ZA
dc.subject Sumatriptan en_ZA
dc.subject Pathophysiology of alcoholism en_ZA
dc.subject Serotonin agonists en_ZA
dc.title Pharmacological challenge with a serotonin 1D agonist in alcohol dependence en_ZA
dc.type Article en_ZA
dc.date.updated 2010-11-09T13:08:30Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder Vythilingum et al.; licensee BioMed Central Ltd. en_ZA


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