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dc.contributor.authorVarghese, Alex C.
dc.contributor.authorDu Plessis, Stefan S.
dc.contributor.authorFalcone, Tommaso 
dc.contributor.authorAgarwal, Ashok 
dc.date.accessioned2010-12-14T10:00:35Z
dc.date.available2010-12-14T10:00:35Z
dc.date.issued2008-10
dc.identifier.citationVarghese, AC, Du Plessis, SS, Falcone, T & Agarwal, A 2008, 'Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes: challenges for fertility preservation', Reproductive Biology and Endocrinology, 6(1):47.en_ZA
dc.identifier.issn1477-7827
dc.identifier.otherhttp://dx.doi.org/10.1186/1477-7827-6-47
dc.identifier.urihttp://hdl.handle.net/10019.1/5095
dc.description.abstractCryopreservation of ovarian tissue and in vitro follicle maturation are two emerging techniques for fertility preservation, especially in cancer patients. These treatment regimes are opening up more options and allow for more suitable choices to preserve fertility according to the patient's specific circumstances. If these technologies are to become widely accepted, they need to be safe, easy to perform and must obtain favorable results. The generation of healthy eggs with the normal genetic complement and the ability to develop into viable and healthy embryos requires tight regulation of oocyte development and maturation. Novel freezing techniques such as vitrification, along with whole ovary cryopreservation and three-dimensional follicle cultures, have shown favorable outcomes. The scope of this article is to take a comprehensively look at the challenges still faced in order for these novel technologies to be routinely employed with the aim of successful fertility preservation.en_ZA
dc.format.extent10 p.
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.subjectCryopreservation of ovarian tissueen_ZA
dc.subjectIn vitro follicle maturationen_ZA
dc.subjectFertility preservationen_ZA
dc.subjectCryopreservation of organs, tissues, etc.en
dc.subjectFertilization (Biology)en
dc.titleCryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes : challenges for fertility preservationen_ZA
dc.typeArticleen_ZA
dc.date.updated2010-11-02T19:11:11Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderVarghese et al.; licensee BioMed Central Ltd.en_ZA


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