Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes : challenges for fertility preservation

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dc.contributor.author Varghese, Alex C.
dc.contributor.author Du Plessis, Stefan S.
dc.contributor.author Falcone, Tommaso
dc.contributor.author Agarwal, Ashok
dc.date.accessioned 2010-12-14T10:00:35Z
dc.date.available 2010-12-14T10:00:35Z
dc.date.issued 2008-10
dc.identifier.citation Varghese, AC, Du Plessis, SS, Falcone, T & Agarwal, A 2008, 'Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes: challenges for fertility preservation', Reproductive Biology and Endocrinology, 6(1):47. en_ZA
dc.identifier.issn 1477-7827
dc.identifier.other http://dx.doi.org/10.1186/1477-7827-6-47
dc.identifier.uri http://hdl.handle.net/10019.1/5095
dc.description.abstract Cryopreservation of ovarian tissue and in vitro follicle maturation are two emerging techniques for fertility preservation, especially in cancer patients. These treatment regimes are opening up more options and allow for more suitable choices to preserve fertility according to the patient's specific circumstances. If these technologies are to become widely accepted, they need to be safe, easy to perform and must obtain favorable results. The generation of healthy eggs with the normal genetic complement and the ability to develop into viable and healthy embryos requires tight regulation of oocyte development and maturation. Novel freezing techniques such as vitrification, along with whole ovary cryopreservation and three-dimensional follicle cultures, have shown favorable outcomes. The scope of this article is to take a comprehensively look at the challenges still faced in order for these novel technologies to be routinely employed with the aim of successful fertility preservation. en_ZA
dc.format.extent 10 p.
dc.language.iso en_ZA en_ZA
dc.publisher BioMed Central en_ZA
dc.subject Cryopreservation of ovarian tissue en_ZA
dc.subject In vitro follicle maturation en_ZA
dc.subject Fertility preservation en_ZA
dc.subject Cryopreservation of organs, tissues, etc. en
dc.subject Fertilization (Biology) en
dc.title Cryopreservation/transplantation of ovarian tissue and in vitro maturation of follicles and oocytes : challenges for fertility preservation en_ZA
dc.type Article en_ZA
dc.date.updated 2010-11-02T19:11:11Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder Varghese et al.; licensee BioMed Central Ltd. en_ZA


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