Doctoral Degrees (Biochemistry)
Recent Submissions
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Investigating the mechanism of action of hormones used in hormone replacement therapy via estrogen receptor subtypes and the influence of the progesterone receptor
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Estrogens and progestins used in conventional menopausal hormone therapy (HT) are associated with increased breast cancer risk. A diverse range of estrogens and progestins are available that mediate ... -
Homologous down-regulation of the glucocorticoid receptor is influenced by the dimerization state of the receptor
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Glucocorticoids (GCs) remain the mainstay therapeutic choice for the treatment of inflammation, and exert their potent anti-inflammatory effects via the glucocorticoid receptor (GRα). However, the chronic ... -
The metabolism of 11β-hydroxyandrostenedione by steroidogenic enzymes yields metabolites contributing to the androgen pool in prostate cancer
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: This study describes: • The development and validation of three ultra-performance convergence chromatography tandem mass spectrometry (UPC2-MS/MS) analytical methods which were applied in the detection ... -
The influence of sutherlandia frutescens on adrenal steroid hormones and downstream receptor interactions
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT: The study was aimed at: 1. linking anti-stress properties of Sutherlandia frutescens to its influence on adrenal steroid biosynthesis in terms of extracts, sutherlandioside (SU) compounds and ... -
Engineering and application of glycosidase derived biocatalysts in the study of mycothiol pathway enzymes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Glycosides are complex carbohydrates that are involved in essential cellular and molecular biological processes within all living organisms. In addition, certain glycosides have anti-cancer, antioxidant, ... -
The biochemical study of the R- and S-enantiomers of 2-(4-acetoxyphenyl)-2-chloro-Nmethylethylammonium chloride (Compound A).
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: The study describes: . The synthesis of a racemic mixture of Compound A (2-(4-acetoxyphenyl)-2-chloro-N-methylethylammonium chloride), a synthetic analogue of the active compound isolated from the African ... -
Phylogenetics of the genus Erica and anthocyanin synthesis gene expression in Erica plukenetii
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: The drivers of species radiations are central to questions about the evolution of diversity. The flora of the Cape Floristic Region (CFR) is particularly diverse, has exceptionally high level of endemism ... -
Partial characterization of lentil seed lipoxygenases and their impact in wheat (Triticum aestivum L.) bread making
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: This study describes: 1. The evaluation of lentil seed flour as an alternative for soybean seed flour; as a source of lipoxygenase during the making of white bread. 2. The development of efficient, and ... -
Development of an integrated metabolic analysis toolbox
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Life is arguably the most complex of all natural phenomena, yet it arises from essentially dead molecular components. The goal of systems biology is to be able to understand how the properties and ... -
Biofilms as multifunctional surface coatings and adaptive systems: a biomimetic approach
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Biomimicry is an emerging scientific discipline that promotes nature-inspired innovation for sustainable solutions. Several patterns and survival strategies are repeated in Nature and these have been ... -
A high rate biofilm contact reactor for winery wastewater treatment
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Winemaking produces variable volumes wastewater rich in biodegradable organic material, with fluctuating chemical composition and pH values according to the seasonal activities of the cellar. Releasing ... -
Optimised bacterial production and characterisation of natural antimicrobial peptides with potential application in agriculture
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT : The loss incurred due to microbial spoilage is a great concern to the agricultural and food industries. Microbial pathogens have typically been controlled through the use of chemical control agents and ... -
A comparative analysis of CoA biosynthesis in selected organisms: a metabolite study
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH SUMMARY: This study investigated the biochemical regulation of CoA production because it is an essential pathway that presents an important target for antimicrobial drug discovery studies. Currently, the specific ... -
The development of a DNA vaccine against Mycoplasma nasistruthionis sp. nov. for use in ostriches
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Mycoplasma nasistruthionis sp. nov. str. Ms03 (Ms03) is one of three Mycoplasma species that were identified from ostriches. Mycoplasmas infections have been implicated in ostrich chick mortalities, ... -
A biochemical study of the effect of ultraviolet treatment on bovine milk and Cheddar cheese
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: This study describes: 1. The evaluation of a novel, patented thin-film, turbulent-flow Ultravioletdisinfection system as an alternative processing method to thermal pasteurisationfor the disinfection of ... -
Coenzyme A biosynthesis and Coenzyme A-dependent redox processes as targets for anti-staphylococcal drug development
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH SUMMARY: Staphylococcus aureus, the bacterium that causes most hospital-acquired in humans is rapidly becoming more prevalent in the community and, alarmingly, increasingly resistant to the current arsenal of ... -
The inhibition of adrenal steroidogenic enzymes and modulation of glucocorticoid levels in vitro and in vivo by aspalathus linearis (rooibos)
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: This study describes: • the influence of a methanolic extract of unfermented Rooibos and five major Rooibos flavonoids, aspalathin, nothofagin, rutin, orientin and vitexin, on the activities of key ... -
Coenzyme a biosynthesis and utilization in Plasmodium falciparum : drug targets for antimalarial chemotherapy
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Pantothenate (also known as Vitamin B5) is the sole precursor of the essential enzyme cofactor coenzyme A (CoA) that is required in several metabolic reactions virtually in all living organisms including ... -
Phytoestrogenic extracts of Cyclopia modulate molecular targets involved in the prevention and treatment of breast cancer
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Phytoestrogen containing extracts of Cyclopia, an indigenous South African fynbos plant used to prepare honeybush tea, may serve as a source of new estrogen analogues. It would be of great benefit if these ... -
Tyrocidines, cyclic decapeptides produced by soil bacilli, as potent inhibitors of fungal pathogens
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: The global rise in microbial resistance, ranging from the agricultural industry to the medical sector, has created the urgent need for novel or supplementary antibiotics. Antimicrobial peptides or ...
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