• Tyrocidines, cyclic decapeptides produced by soil bacilli, as potent inhibitors of fungal pathogens 

  Troskie, Anscha Mari (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: The global rise in microbial resistance, ranging from the agricultural industry to the medical sector, has created the urgent need for novel or supplementary antibiotics. Antimicrobial peptides or ...
• Characterisation of small cyclic peptides with antilisterial and antimalarial activity 

  Leussa, Nyango-Nkeh Adrienne (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Antimicrobial peptides (AMPs) are currently the most researched group of compounds for new antimicrobial drugs especially with the rise in resistance to almost all available drugs by public health ...
• The synthesis and characterisation of analogues of the antimicrobial peptide iturin A₂ 

  Rautenbach, Marina (Stellenbosch : Stellenbosch University, 1998-12)

  ENGLISH ABSTRACT: Iturin A, an antifungal lipopeptide, is produced by Bacillus subtilis. This cyclic peptide consists of seven D- and L-amino acid residues (L-Asn2-D-Tyr3-D-Asn4-L-Gln5-L-Pro6-DAsn7- L-Ser8) and a beta-amino ...
• Understanding glycolysis in Escherichia coli : a systems approach using nuclear magnetic resonance spectroscopy 

  Eicher, Johann Josef (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: This dissertation explores the behaviour and regulation of central carbon metabolism in Escherichia coli K12 W3110 under fermentative microaerobic conditions. To achieve this, an integrative systems modelling ...
• Chemopreventive properties of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp) : mechanisms against skin carcinogenesis 

  Magcwebeba, Tandeka Unathi (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: The present study employed a two-phased approach to investigate the possible mechanisms involved in the chemopreventive properties of rooibos (Aspalathus linearis) and different honeybush species (Cyclopia ...
• Altered lipid metabolism as a possible mechanism in fumonisin-induced hepatocarcinogenesis in rats and investigations into risk assessment in humans 

  Burger, Hester Maria (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Exposure to food contaminates such as mycotoxins have been associated with a variety of animal and human diseases worldwide. In South Africa, maize is the most To further refine risk assessment in the ...
• A kinetic model of glucose catabolism in Plasmodium falciparum 

  Penkler, Gerald Patrick (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Malaria infects over 200 million individuals and leads to the death of over 600 000 people annually. Currently artemisinin combination therapy treatments are effective in treating the disease, but ...
• The regulatory design of glycogen metabolism in mammalian skeletal muscle 

  Palm, Daniel Christiaan (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: It is widely accepted that insufficient insulin-stimulated activation of muscle glycogen synthesis is one of the major components of non-insulin-dependent (type 2) diabetes mellitus. Glycogen synthase, ...
• A study of the molecular mechanism of progestin-induced regulation of IL-12 and IL-10 and implications for HIV pathogenesis 

  Louw, Renate (Stellenbosch : Stellenbosch University, 2013-03)

  ENGLISH ABSTRACT: Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives (norethisterone enanthate (NET-EN); norethisterone acetate (NET-A)), designed to mimic the actions of the endogenous hormone ...
• A study of the strain evolution and recombination of South African isolates of Potato virus Y 

  Visser, Johan Christiaan (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Potato virus Y (PVY) is responsible for considerable yield losses in the South African potato industry. The incidence of this virus has greatly increased over the past 20 years. In previous studies ...
• The influence of 3βHSD on adrenal steroidogenesis and the factors which influence its activity 

  Goosen, Pierre (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: This study describes: - the characterization and comparison of the enzymatic activity of both Angora and ovine 3βHSD expressed in non-steroidogenic COS-1 cells. The apparent Km and Vmax values for ...
• Immunological and epidemiological investigations in South African ostriches and penguins 

  Botes, Annelise (Stellenbosch : Stellenbosch University, 2004-04)

  ENGLISH ABSTRACT: Newcastle disease (NO) and mycoplasma infections in ostriches have considerable economic implications for the South African ostrich industry in that NO is a limiting factor in the export of ostrich ...
• Investigation of glucocorticoid and dissociated glucocorticoid activity in hepatoma cell lines with specific reference to regulation of the corticosteroid binding globulin (CBG) proximal promoter' 

  Allie-Reid, Fatima (Stellenbosch : Stellenbosch University, 2003-12)

  ENGLISH ABSTRACT: This study investigated the effect of several hormones on the rat corticosteroid binding globulin proximal promotor and for the first time showed that modulation occurs at the promotor level and can ...
• Differential protein expression focusing on the mannose phosphotransferase system, in Listeria monocytogenes strains with class 11a bacteriocin resistance 

  Ramnath, Manilduth (Stellenbosch : Stellenbosch University, 2003-12)

  ENGLISH ABSTRACT: Please refer to fulltext for abstract
• Changes in cell surface and metabolism associated with strains of Listeria monocytogenes displaying different sensitivities to class IIa bacteriocins 

  Vadyvaloo, Viveka (Stellenbosch : Stellenbosch University, 2003-12)

  ENGLISH ABSTRACT: The possible use of the bacterially produced antimicrobial peptides, and in particular class IIa bacteriocins as food preservatives is a motivating factor in studies on resistance to them by food-borne ...
• Isolation and characterisation of a polygalacturonase-inhibiting protein (PGIP) and its encoding gene from Vitis vinifera L. 

  De Ascensao, Ana (Stellenbosch : Stellenbosch University, 2001-12)

  ENGLISH ABSTRACT: Polygalacturonase-inhibiting proteins (PGIPs) are present in the cell walls of a variety of plant species. These proteins have been shown to specifically inhibit endopolygalacturonases (endo-PGs) ...
• Cloning and identification of genes involved in the interaction between the bacterial stone fruit pathogen Pseudomonas syringae pv. syringae strain NV and plum trees 

  Appel, Maryke (Stellenbosch : Stellenbosch University, 2001-03)

  ENGLISH ABSTRACT: Bacterial canker of stone fruit, caused by Pseudomonas syringae pv. syringae, is one of the most destructive crop diseases in South Africa. Chemical control has failed completely and effective long-term ...
• Investigation of malt factors that influence beer production and quality 

  Van Nierop, Sandra (Stellenbosch : Stellenbosch University, 2005-03)

  ENGLISH ABSTRACT: A number of relevant brewing industry issues associated with malt quality were examined. These included beer foam quality, premature flocculation of yeast during fermentation and antimicrobial factors ...
• Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays 

  Marnewick, Jeanine Lucasta (Stellenbosch : Stellenbosch University, 2004-12)

  ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing ...
• Identification of candidate genes and testing for association with tuberculosis in humans 

  Babb, Chantal Louiza (Stellenbosch : Stellenbosch University, 2007-12)

  ENGLISH ABSTRACT: This research investigated human candidate genes for susceptibility to tuberculosis and the effect of various factors on time to sputum conversion in the admixed South African Coloured (SAC) population. ...

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