SUNScholar
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Faculty of Science
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Department of Biochemistry
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Doctoral Degrees (Biochemistry)

Doctoral Degrees (Biochemistry)

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Recent Submissions

The synthesis and characterisation of analogues of the antimicrobial peptide iturin A₂

Rautenbach, Marina (Stellenbosch : Stellenbosch University, 1998-12)

ENGLISH ABSTRACT: Iturin A, an antifungal lipopeptide, is produced by Bacillus subtilis. This cyclic peptide consists of seven D- and L-amino acid residues (L-Asn2-D-Tyr3-D-Asn4-L-Gln5-L-Pro6-DAsn7- L-Ser8) and a beta-amino ...
Understanding glycolysis in Escherichia coli : a systems approach using nuclear magnetic resonance spectroscopy

Eicher, Johann Josef (Stellenbosch : Stellenbosch University, 2013-12)

ENGLISH ABSTRACT: This dissertation explores the behaviour and regulation of central carbon metabolism in Escherichia coli K12 W3110 under fermentative microaerobic conditions. To achieve this, an integrative systems modelling ...
Chemopreventive properties of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp) : mechanisms against skin carcinogenesis

Magcwebeba, Tandeka Unathi (Stellenbosch : Stellenbosch University, 2013-12)

ENGLISH ABSTRACT: The present study employed a two-phased approach to investigate the possible mechanisms involved in the chemopreventive properties of rooibos (Aspalathus linearis) and different honeybush species (Cyclopia ...
Altered lipid metabolism as a possible mechanism in fumonisin-induced hepatocarcinogenesis in rats and investigations into risk assessment in humans

Burger, Hester Maria (Stellenbosch : Stellenbosch University, 2013-12)

ENGLISH ABSTRACT: Exposure to food contaminates such as mycotoxins have been associated with a variety of animal and human diseases worldwide. In South Africa, maize is the most To further refine risk assessment in the ...
A kinetic model of glucose catabolism in Plasmodium falciparum

Penkler, Gerald Patrick (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: Malaria infects over 200 million individuals and leads to the death of over 600 000 people annually. Currently artemisinin combination therapy treatments are effective in treating the disease, but ...
The regulatory design of glycogen metabolism in mammalian skeletal muscle

Palm, Daniel Christiaan (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: It is widely accepted that insufficient insulin-stimulated activation of muscle glycogen synthesis is one of the major components of non-insulin-dependent (type 2) diabetes mellitus. Glycogen synthase, ...
A study of the strain evolution and recombination of South African isolates of Potato virus Y

Visser, Johan Christiaan (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Potato virus Y (PVY) is responsible for considerable yield losses in the South African potato industry. The incidence of this virus has greatly increased over the past 20 years. In previous studies ...
The influence of 3βHSD on adrenal steroidogenesis and the factors which influence its activity

Goosen, Pierre (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: This study describes: - the characterization and comparison of the enzymatic activity of both Angora and ovine 3βHSD expressed in non-steroidogenic COS-1 cells. The apparent Km and Vmax values for ...
Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays

Marnewick, Jeanine Lucasta (Stellenbosch : Stellenbosch University, 2004-12)

ENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing ...
Identification of candidate genes and testing for association with tuberculosis in humans

Babb, Chantal Louiza (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: This research investigated human candidate genes for susceptibility to tuberculosis and the effect of various factors on time to sputum conversion in the admixed South African Coloured (SAC) population. ...
Comparison of two CYP17 isoforms : implications for cortisol production in the South African Merino

Hough, Denise (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: This study describes: • the comparison of the enzymatic activities of the two ovine cytochrome P450 17 - hydroxylase/17,20-lyase (CYP17) isoforms expressed in non-steroidogenic COS-1 cells. The Km and ...
Transcriptional regulation of the gonadotropin-releasing hormone receptor (GnRHR) gene by glucocorticoids

Fernandes, S. M. (Sandra Maria) (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: The gonadotropin-releasing hormone (GnRH) receptor is a G-protein-coupled receptor in the pituitary gonadotropes and is an important control point for reproduction. GnRH binds to the GnRH receptor (GnRHR) ...
A biochemical study of tissue type plasminogen activator in bovine milk

Cilliers, Frans Pieter (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: This study describes: 1. The isolation and the purification of tissue type plasminogen activator and urokinase plasminogen activator in bovine milk. 2. The biochemical characterisation of tissue type ...
The isolation and charcterisation of ovine liver cytochrome b₅

Lombard, Nicolaas (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: This dissertation describes how the isolation and characterisation of ovine liver cytochrome b5 was accomplished by referring to the following goals achieved in this study: - The optimisation of the ...
Molecular phylogenetic relationships within the subtribe Disinae (Orchidaceae) and their taxonomic, phytogeographic and evolutionary implications

Bytebier, Benny (Benny Leopold Germaine) (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: Twenty five years after the last major morphological revision, phylogenetic relationships were inferred on the basis of a new DNA dataset for the African orchid subtribe Disinae, which includes the large ...
Cape baboon Cytochrome P450 11β-hydroxylases : the characterization of two functional enzymes

Brown, Natasja (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: This study: 1. Describes the localization of CYP11B1 in the Cape baboon adrenal gland using Western blot analysis. CYP11B1 was localized to the adrenal cortex and medulla. 2. Describes the catalytic ...
The mammalian type II gonadotropin-releasing hormone receptor : cloning, distribution and role in gonadotropin gene expression

Van Biljon, Wilma (Stellenbosch : University of Stellenbosch, 2006-12)

ENGLISH ABSTRACT: Gonadotropin-releasing hormone (GnRH) is well known as the central regulator of the reproductive system through its stimulation of gonadotropin synthesis and release from the pituitary via binding to ...
Characteristics and adaptation of skeletal muscle to endurance exercise

Kohn, Tertius A. (Stellenbosch : University of Stellenbosch, 2011-10)

ENGLISH ABSTRACT: Skeletal muscle adapts to stimuli by modifying structural and metabolic protein expression. Furthermore, a muscle group may vary within itself to accommodate specialisation in regions. Structural and ...
Bioaffinity separation using ligand-modified pluronic and synthetic membranes

Govender, Selvakumaran (Stellenbosch : University of Stellenbosch, 2011-10)

ENGLISH ABSTRACT: A new membrane based affinity separation system that is bio-specific, biocompatible, well characterised and capable of being regenerated or re-used is described. The amphiphilic non-ionic surfactant ...
Role of surfactin from Bacillus subtilis in protection against antimicrobial peptides produced by Bacillus species

Eyeghe-Bickong, Hans Andre (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: Antagonism of antimicrobial action represents an alternative survival strategy for cohabiting soil organisms. Under competitive conditions, our group previously showed that surfactin (Srf) produced by ...

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