Alcohol Induced Psychotic Disorder: a comparitive study in patients with alcohol dependance, schizophrenia and normal controls

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dc.contributor.author Jordaan, Gerhard
dc.contributor.author Emsley, R. A.
dc.contributor.other University of Stellenbosch. Faculty of Health Sciences. Dept. of Psychiatry. en_ZA
dc.date.accessioned 2010-07-28T05:27:50Z
dc.date.available 2010-07-28T05:27:50Z
dc.date.issued 2007-12
dc.identifier.citation Jordaan, G 2007,'Alcohol Induced Psychotic Disorder: a comparitive study in patients with alcohol dependance, schizophrenia and normal controls',Stellenbosch University, Stellenbosch. en_ZA
dc.identifier.uri http://hdl.handle.net/10019.1/3791
dc.description Thesis(DMed (Psychiatry))-- University of Stellenbosch, 2007. en_ZA
dc.description.abstract Alcohol-induced psychotic disorder (also known as alcohol hallucinosis) is a complication of alcohol abuse that requires clinical differentiation from alcohol withdrawal delirium and schizophrenia. Although extensively described, few studies utilized standardized research instruments and brain-imaging has thus far been limited to case reports. The aim of this study was to prospectively compare four population groups (ie. patients with alcohol-induced psychotic disorder, schizophrenia, uncomplicated alcohol dependence and a healthy volunteer group) according to demographic, psychopathological and brainimaging variables utilizing (i) rating scales and (ii) single photon emission computed tomography (SPECT). The third component of the study was designed to investigate the (iii) effect of anti-psychotic treatment on the psychopathology and regional cerebral blood flow (rCBF) before and after six weeks of treatment with haloperidol. Effort was made to ensure exclusion of comorbid medical disorders, including substance abuse. The study provides further supportive evidence that alcohol-induced psychotic disorder can be distinguished from schizophrenia. Statistically significant differences in rCBF were demonstrated between the alcohol-induced psychotic disorder and other groups. Changes in frontal, temporal, parietal, occipital, thalamic and cerebellar rCBF showed statistically significant negative correlations with post-treatment improvement on psychopathological variables and imply dysfunction of these areas in alcohol-induced psychotic disorder. The study was unable to distinguish between pharmacological effects and improvement acccomplished by abstinence from alcohol. en_ZA
dc.description.sponsorship Stellenbosch: Stellenbosch University en_ZA
dc.language.iso en en_ZA
dc.publisher Stellenbosch : University of Stellenbosch en_ZA
dc.subject Dissertations -- Psychiatry en_ZA
dc.subject Alcohol en_ZA
dc.subject Psychopathological en_ZA
dc.subject Deleruim en_ZA
dc.subject Schizophrenia en_ZA
dc.subject Hallucinosis en_ZA
dc.subject Theses -- Psychiatry en
dc.title Alcohol Induced Psychotic Disorder: a comparitive study in patients with alcohol dependance, schizophrenia and normal controls en_ZA
dc.type Thesis en_ZA
dc.rights.holder University of Stellenbosch en_ZA


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