Doctoral Degrees (Medical Physiology)

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The role of Protein Phosphatase 2A (PP2A) in myocardial ischaemia/reperfusion injury

Van Vuuren, Derick (Stellenbosch : Stellenbosch University, 2014-04)

ENGLISH ABSTRACT: Ischaemic heart disease is a major contributor to global morbidity and mortality rates. Manoeuvres such as ischaemic preconditioning confer cardioprotection against ischaemia/reperfusion (I/R) injury ...
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states

Nduhirabandi, Frederic (Stellenbosch : Stellenbosch University, 2014-04)

ENGLISH ABSTRACT: Introduction: The cardioprotective actions of the hormone melatonin against myocardial ischaemiareperfusion injury (IRI) are well-established. It has recently been shown to prevent the harmful effects ...
Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms

Genis, Amanda (Stellenbosch : Stellenbosch University, 2014-04)

ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ...
Ischaemic preconditioning : an investigation of the patterns of kinase activation and protein expression profiles during reperfusion in the rat heart

Hattingh, Susanna Maria (Suzel) (Stellenbosch : Stellenbosch University, 2013-12)

ENGLISH ABSTRACT: Introduction: Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying globally each year. Although existing myocardial reperfusion strategies ...
The impact of obesity and chronic PPAR Alpha agonist treatment on cardiac function, metabolism and ischaemic tolerance

Smith, Wayne (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Background: Myocardial oxidative fuel supply is increased in obese conditions. How this metabolic environment and altered cardiometabolic phenotype associated with prediabetic obesity impacts on cardiac ...
The mechanism of pharmacological preconditioning of rat myocardium with beta-adrenergic agonists

Salie, Ruduwaan (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: The Mechanism of -adrenergic preconditioning ( -PC) Ischaemic preconditioning (IPC), a potent endogenous protective intervention against myocardial ischaemia, is induced by exposure of the heart to ...
Immunohaematopoietic stem and progenitor cell transplantation - a thirty year prospective and systematic research investigation

Jacobs, Peter (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: See full text for abstract
The effect of creatine supplementation on myocardial metabolism and function in sedentary and exercised rats

Webster, Ingrid (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: Background: There has been a dramatic increase in the use of dietary creatine supplementation among sports men and women, and by clinicians as a therapeutic agent in muscular and neurological diseases. ...
A proteomic and neurochemical analysis of the effects of early life stress on drug addiction and post abuse therapeutic interventions : an animal study

Faure, Jacqueline Jeanette (Stellenbosch : University of Stellenbosch, 2010-03)

ENGLISH ABSTRACT: Psychosocial stressors have frequently been associated with an increased risk for developing The contributions of the cholinergic (Lobeline) and opioid (Naltrexone) systems in place preference behaviour ...
The potential of exercise to reverse stress induced abnormalities in the rat brain

Marais, Lelanie (Stellenbosch : University of Stellenbosch, 2010-03)

ENGLISH ABSTRACT: Adverse experiences during early life causes alterations in the development of the central nervous system structures that may result in abnormal functioning of the brain. It is well known that, in humans, ...
Effects of insulin and leptin on human spermatozoa function and their cross-talk with nitric oxide and cytokines

Lampiao, Fanuel (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: In recent years there has been an increase in obesity and diabetes mellitus (DM). These conditions have for a long time been associated with infertility. Obesity is characterized by high levels of ...
The impact of developmental stress on the functioning and vulnerability of CNS neurons

Pienaar, Ilse-Sanet (Stellenbosch : Stellenbosch University, 2008-12)

The overall objective of this thesis is to provide additional data to assist clinicians and experimental neurologists alike in the quest for better understanding, more accurately diagnosing and more successfully treating ...
The effects of early life trauma on the neurochemistry and behaviour of the adult rat

Uys, Joachim De Klerk (Stellenbosch : University of Stellenbosch, 2006-12)

Early life trauma leads to behavioural abnormalities later in life. These include mood and anxiety disorders such as depression and posttraumatic stress disorder (PTSD). This association may be due in part to the effects ...
Hypoxia and the heart : the role of nitric oxide in cardiac myocytes and endothelial cells

Strijdom, Hans (Stellenbosch : University of Stellenbosch, 2007-03)

Nitric oxide (NO) is a major signaling molecule in the heart with various biological effects. The putative role of NO as a cardioprotective agent against ischaemiareperfusion injury and in ischaemic preconditioning (IP) ...

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