Doctoral Degrees (Medical Physiology)
Recent Submissions
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Epacs exchange protein directly activated by cAMP role in obesity-induced cardiovascular diseases
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Introduction and aims: The strong association between obesity and cardiovascular diseases (CVD) stresses the necessity of elucidating the underlying molecular mechanisms linking these pathologies. ... -
HIV/AIDS and air pollution as emerging cardiovascular risk factors in Cape Town populations : is endothelial function a marker of effect
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Background: HIV and antiretroviral therapy (ART) are associated with cardiovascular disease (CVD). Concomitantly,air pollution is a global health concern and associated with CVD. Although South Africa ... -
The Possible Ameliorating effects of Rooibos, Honeybush and Sutherlandia on diabetes-induced reproductive impairment in adult male Wistar rats
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: The global prevalence of infertility is on the rise, and so is male factor infertility. Out of the approximately 72.4 million infertile couples worldwide, male factor is responsible for 50%. It has ... -
Protein phosphorylation in Ischaemia and reperfusion of the heart : a focus on protein phosphatase 2A
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Understanding the mechanism and signalling pathways involved in myocardial ischaemia/reperfusion (I/R) injury is a prerequisite for elucidating any novel therapeutic intervention to reduce I/R injury. ... -
The effects of a green rooibos extract on the reproductive function of obesity-induced insulin resistant or hypertensive male wistar rats
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Diet-induced obesity (DIO) due to a high caloric diet (HCD) predisposes an individual to the development of diabetes and cardiovascular diseases, with high prevalence in young populations. Existing evidence ... -
The effect of green rooibos extract on rat hearts in a pre-diabetic model : an evaluation of the function and mechanisms involved
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Background— Cardiovascular diseases (CVD) remains the leading cause of death globally, with a rising prevalence of individual risk factors such as obesity and insulin resistance. Furthermore, diabetic ... -
An investigation into the role of ATM protein in mitochondrial defects associated with cardiovascular pathology resulting from insulin resistance
(Stellenbosch : Stellenbosch University, 2019-04)Background: Ataxia-telangiectasia (A-T) is a rare, recessive disorder that develops in the absence of Ataxia-Telangiectasia Mutated protein kinase (ATM). This complex disease is characterised by neurodegeneration, increased ... -
The manipulation of autophagy during early and late reperfusion : the effect on myocardial protection
(Stellenbosch : Stellenbosch University, 2019-03)ENGLISH ABSTRACT: Introduction: Ischemic heart disease, the leading cause of death worldwide, often has devastating effects on myocardial function. ReFestablishment of coronary flow to salvage myocardial cells results in ... -
Basic semen parameters assisted by Computer-Aided sperm analysis (CASA) and their correlations with advanced semen parameters in normozoospermic men with different abstinence periods
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: Affordable basic semen analysis remains a fundamental procedure to be performed routinely during the diagnosis of male infertility. Advanced semen analyses, provide valuable clinical insights in treatment ... -
Contribution of highly active anti-retroviral therapy to the development of non-alcoholic fatty liver disease with concomitant cardiovascular dysfunction in an obese rat model
(Stellenbosch : Stellenbosch University, 2018-03)Introduction: HIV/AIDS mortality is declining due to successful highly active anti-retroviral therapy (HAART). However, obesity, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) in treated ... -
Effect of different substrates on functional performance and kinase activation during reperfusion after ischaemia in hearts from obese insulin resistant rats
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Obesity is an important risk factor for the development of insulin resistance, the metabolic syndrome and diabetes and has also been implicated as one of the major risk factors for coronary heart disease. ... -
An investigation into the importance of the ATM protein in the myocardial pathology associated with insulin resistance and type 2 diabetes
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Introduction: Ataxia-telangiectasia (A-T) is an autosomal, recessive disorder that is caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. The gene product, ATM, is a 350 kDa serine/threonine ... -
An investigation into the anti-obesity properties of Cyclopia
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH SUMMARY: Polyphenols have a range of health promoting effects against chronic diseases such as obesity and type 2 diabetes mellitus. Previous research in our group showed that Cyclopia species (honeybush), endemic ... -
Rooibos and Melatonin: Putative modulation of nicotine-induced effects on vascular function
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : Introduction and aims: Cigarette smoking is an important risk factor for cardiovascular disease, and nicotine, the addictive substance in tobacco, is implicated in the pathogenesis of atherosclerosis ... -
Compounds specific to Aspalathus linearis protects the diabetic heart against oxidative stress: a mechanistic study
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT : In diabetics, hyperglycemia, hyperlipidemia and inflammation potentiates the development of cardiovascular diseases (CVDs). These conditions provoke excessive generation of oxidative stress that has been ... -
The dietary ionic effects on sex ratios in animal models
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: X-linked disorders are more expressed in male offspring and prevention of these hereditary diseases is the only recourse to date. Influencing conception towards female offspring can circumvent this problem; ... -
Gamete proteomic profile of male patients suffering from sexually transmitted infections
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The aim of this study was to provide better insight into the effects of Neisseria gonorrhoea, Chlamydia trachomatis, and Trichomonas vaginalis on semen characteristics. In addition, a crucial focus was ... -
Next generation sequencing demonstrates minor variant HIV drug resistance mutations
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Introduction: The South African public sector antiretroviral therapy (ART) roll-out has been associated with emergence of HIV drug resistance (HIVDR) in therapy-naïve and treated patients. These drug-resistant ... -
The responses of endothelium to insult : does endothelial heterogeneity play a role in in vitro cell models
(Stellenbosch : Stellenbosch University, 2015-12)ENGLISH ABSTRACT: Endothelial injury and dysfunction precede the development of cardiovascular diseases. The endothelium may be regarded as the first line of defence against inflammation / obesity-induced vascular injury, ... -
Investigating the cholesterol-independent (pleiotropic) effects of selected hypolipidaemic agents in functional and dysfunctional endothelial cells
(Stellenbosch : Stellenbosch University, 2015-03)ENGLISH ABSTRACT: Vascular endothelium forms the first line of defence against harmful stimuli in the circulation. Endothelial dysfunction is a valuable predictor of cardiovascular disease and therapies aimed at improving ...
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