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High tuberculosis exposure among neonates in a high tuberculosis and human immunodeficiency virus burden setting

dc.contributor.authorBekker A.
dc.contributor.authorDu Preez K.
dc.contributor.authorSchaaf H.S.
dc.contributor.authorCotton M.F.
dc.contributor.authorHesseling A.C.
dc.date.accessioned2012-07-26T07:16:16Z
dc.date.available2012-07-26T07:16:16Z
dc.date.issued2012
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation16
dc.identifier.citation8
dc.identifier.citation1040
dc.identifier.citation1046
dc.identifier.issn10273719
dc.identifier.otherdoi:10.5588/ijtld.11.0821
dc.identifier.urihttp://hdl.handle.net/10019.1/21815
dc.descriptionArticle
dc.description.abstractBACKGROUND: Maternal and neonatal tuberculosis (TB) are under-recognised, particularly in settings with a high burden of human immunodeficiency virus (HIV) infection. DESIGN AND SETTING: Retrospective audit of neonates routinely screened for TB in a South African hospital during 2009. Surveillance sources reviewed included routine clinical, laboratory and pharmacy records. RESULTS: Among 70 neonates (60% HIV-exposed) screened for TB, the median gestational age was 35.5 weeks (IQR 33-38), and the median birth weight was 2000 g (IQR 1530-2484). The neonates were grouped according to a history of documented TB exposure: maternal TB in 41/70 (59%), suspected maternal TB in 9/70 (13%), other documented household TB exposure in 5/70 (7%), and no known TB exposure 15/70 (21%). Of the 50 neonates exposed to confirmed or suspected maternal TB, 36 (72%) were initiated on TB chemoprophylaxis, 5 (10%) received TB treatment and 9 (18%) received no intervention. Eight (8/50, 16%) were diagnosed with TB, all of whom were born to mothers with suspected or proven TB. CONCLUSIONS: Maternal TB, primarily among HIV-infected women, was the main indication for TB screening of neonates. Routine TB screening of pregnant women and TB care in mothers and infants should be improved in settings with a high burden of TB and HIV. © 2012 The Union.
dc.subjectIPT
dc.subjectLow birth weight
dc.subjectNewborns
dc.subjectOutcome
dc.subjectTB treatment
dc.titleHigh tuberculosis exposure among neonates in a high tuberculosis and human immunodeficiency virus burden setting


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