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In search of a treatment for HIV - Current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Reynolds C. ; De Koning C.B. ; Pelly S.C. ; Van Otterlo W.A.L. ; Bode M.L. (2012)


The human immunodeficiency virus (HIV) causes AIDS (acquired immune deficiency syndrome), a disease in which the immune system progressively deteriorates, making sufferers vulnerable to all manner of opportunistic infections. Currently, world-wide there are estimated to be 34 million people living with HIV, with the vast majority of these living in sub-Saharan Africa. Therefore, an important research focus is development of new drugs that can be used in the treatment of HIV/AIDS. This review gives an overview of the disease and addresses the drugs currently used for treatment, with specific emphasis on new developments within the class of allosteric non-nucleoside reverse transcriptase inhibitors (NNRTIs). © 2012 The Royal Society of Chemistry.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/21576
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