Health Claims on the Benefits of Moderate Alcohol Consumption in Relation to Genetic Profiles

van Velden D.P. ; Kotze M.J. ; Blackhurst D.M. ; Marnewick J.L. ; Kidd M. (2011)


A total of 43 individuals were included in a study of genetic and environmental factors associated with cardiovascular disease; seven subjects (16%) were diagnosed with the metabolic syndrome. A statistically significant association was observed between the E2 allele of the apolipoprotein E (Apo E) polymorphism and an increasing number of metabolic syndrome features (p = 0.03). Clinical and biochemical abnormalities identified could be ascribed to the combined effects of unfavorable genotypes and environmental factors known to interact with the Apo E gene. Excessive alcohol intake, high-calorie diets and smoking should be restricted in individuals with the Apo E2 and/or E4 alleles, which are associated with a significantly increased risk of cardiovascular disease. © 2011 Copyright Taylor and Francis Group, LLC.

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