Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats

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dc.contributor.author Louw, Ann
dc.contributor.author Swart, P.
dc.date.accessioned 2012-02-09T15:18:41Z
dc.date.issued 1999-05
dc.identifier.citation Louw, A. & Swart, P. 1999. Salsola tuberculatiformis Botschantzev and an Aziridine precursor analog mediate the in vivo increase in free Corticosterone and decrease in Corticosteroid-binding globulin in female wistar rats. Endocrinology, 140(5), 2044-2053, doi:10.1210/en.140.5.2044.
dc.identifier.issn 1945-7170 (online)
dc.identifier.issn 0013-7227 (print)
dc.identifier.other doi:10.1210/en.140.5.2044
dc.identifier.uri http://hdl.handle.net/10019.1/19694
dc.description The original publication is available at http://endo.endojournals.org
dc.description.abstract Salsola tuberculatiformis Botschantzev causes prolonged gestation in sheep and contraception in rats. An active fraction isolated from the shrub, containing a highly labile hydoxyphenyl aziridine or precursor, and a more stable analog, compound A, inhibits sheep adrenal cytochrome P450c11. In addition, compound A has been shown to bind to and be stabilized by corticosteroid-binding globulin (CBG). Binding may result in concomitant displacement of endogenous steroids, which could contribute to the biological effects of these compounds. The present study was undertaken to establish which mechanism would predominate in female rats. Compound A significantly (P,0.01) displaced glucocorticoids, but not progesterone, from corticosterone in both S. tuberculatiformis (P , 0.05)- and compound A (P , 0.01)-treated rats was also significantly higher due to displacement from CBG. In addition, both ACTH and CBG concentrations were significantly (P , 0.05) lower than control values. The levels of the gonadotropins were also reduced during treatment, but only LH values significantly (P , 0.05) so. These results suggest that binding of the test substances to CBG in female rat plasma and concomitant displacement of endogenous corticosterone could be part of the contraceptive mechanism of S. tuberculatiformis and the aziridine precursor, compound A. en_ZA
dc.publisher The Endocrine Society en_ZA
dc.subject Glucocorticoids en_ZA
dc.subject Cytochrome P-450 en_ZA
dc.subject Globulins en_ZA
dc.subject Steroid-binding proteins en_ZA
dc.subject Steroid hormones en_ZA
dc.subject Adrenocortical hormones en_ZA
dc.subject Rats -- Physiology en_ZA
dc.title Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats en_ZA
dc.type Article en_ZA
dc.description.version Publishers' version en_ZA
dc.rights.holder The Endocrine Society en_ZA
dc.embargo.terms 2050-12-31 en_ZA
dc.embargo.lift 2050-12-31


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