Medical Virology
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Peripheral blood lymphocyte proviral DNA predicts neurocognitive impairment in clade C HIV
(Springer, 2020-07)It is not known if proviral DNA in the periphery corresponds to cognitive status in clade C as it does in clade B and recombinant forms. A cross-sectional study was conducted on participants investigated for HIV-associated ... -
Delays in HIV-1 infant polymerase chain reaction testing may leave children without confirmed diagnoses in the Western Cape province, South Africa
(AOSIS, 2022-06)Background: Early diagnosis and confirmation of HIV infection in newborns is crucial for expedited initiation of antiretroviral therapy. Confirmatory testing must be done for all children with a reactive HIV PCR result. ... -
Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa
(Frontiers Media, 2020-03)The South African national combination antiretroviral therapy (cART) roll-out program started in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 drug resistance can hamper the ... -
Bimodal distribution and set point HBV DNA viral loads in chronic infection : retrospective analysis of cohorts from the UK and South Africa
(Wellcome Open Research, 2020-10-14)ENGLISH ABSTRACT: Hepatitis B virus (HBV) viral load (VL) is used as a biomarker to assess risk of disease progression, and to determine eligibility for treatment. While there is a well recognised association between VL ... -
Structural comparison of diverse HIV-1 subtypes using molecular modelling and docking analyses of integrase inhibitors
(MDPI, 2020-08-26)ENGLISH ABSTRACT: The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by ... -
Responding to the Challenge of the Dual COVID-19 and Ebola Epidemics in the Democratic Republic of Congo—Priorities for Achieving Control
(2020)Abstract. As of June 11, 2020, the Democratic Republic of the Congo (DRC) has reported 4,258 COVID-19 cases with 90 deaths. With other African countries, the DRC faces the challenge of striking a balance between easing ... -
Turnaround times – the Achilles’ heel of community screening and testing in Cape Town, South Africa: A short report
(AOSISAuthors retain copyright, 2020-10)Early in the course of the coronavirus infection disease 2019 (COVID-19) pandemic in South Africa, the Department of Health implemented a policy of community screening and testing (CST). This was based on a community-orientated ... -
Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring
("Authors retains Copyright", 2020-08)Background: Pooled testing, or pooling, has been used for decades to efficiently diagnose relatively rare conditions, such as infection in blood donors. Programmes for the prevention of mother-to-child transmission of HIV ... -
Rapid testing for respiratory syncytial virus in a resource-limited paediatric intensive care setting
(2020-12-08)We analysed the performance characteristics of the respiratory syncytial virus lateral flow rapid antigen assay in use when compared to a multiplex polymerase chain reaction for detection of respiratory viruses. The study ... -
Analysis of HIV-1 diversity and inflammatory markers in HIV-associated neurocognitive disorders (HAND).
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH SUMMARY: HIV-associated neurocognitive disorders (HAND), which involve impairment or disruption of neurocognitive functioning have become one of the most frequent complications in adult HIV-1 infections with global ... -
A Longitudinal Perspective on the Impact of Immune Status on the HIV-1 Latent Reservoir and Neurocognitive Outcomes in Virologically Suppressed Children
(Stellenbosch : Stellenbosch University, 2022-04)ENGLISH SUMMARY: Background: Children remain the most vulnerable population affected by the Human Immunodeficiency Virus-1 (HIV-1) pandemic whose reliance on lifelong therapy is accompanied by several immune abnormalities. ... -
Hepatitis B virus seroepidemiology data for Africa : modelling intervention strategies based on a systematic review and meta-analysis
(Public Library of Science, 2021-04-21)Background: International Sustainable Development Goals (SDGs) for elimination of hepatitis B virus (HBV) infection set ambitious targets for 2030. In African populations, infant immunisation has been fundamental to reducing ... -
High positive HIV serology results can still be false positive
(Elsevier, 2019)ENGLISH ABSTRACT: The consequences of falsely reactive HIV test results can be significant, for patients and healthcare providers. This case describes a diagnostic investigation of a patient with pronounced discordant HIV ... -
Near full-length HIV-1 subtype B sequences from the early South African epidemic, detecting a BD unique recombinant form (URF) from a sample in 1985
(Nature Research, 2019-04-17)ENGLISH ABSTRACT: HIV-1 subtype C is the most prevalent subtype in South Africa. Although subtype B was previously detected in South Africa, there is limited sequence information available. We characterized near full-length ... -
The effect of interventions on the transmission and spread of HIV in South Africa : a phylodynamic analysis
(Nature Research, 2019-02-25)ENGLISH ABSTRACT: The epidemic in South Africa is characterized by high genetic diversity driven by multiple independent introductions. The bulk of these introductions occurred between 1985–2000 during which time HIV ... -
Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaounde, Cameroon : a longitudinal cohort study
(BMC (part of Springer Nature), 2019)Background: HIV-load decrease and suppression over time is associated with consistent adherence to antiretroviral therapy (ART). Our study aimed to evaluate the difference in viral load and adherence of patients treated ... -
Academic publishing in pandemic times
(ASSAf, 2020-09-21)ENGLISH ABSTRACT: Even though it tends to feel like ages, it has not been that long since the final days of 2019, when cases of severe respiratory illness (now known as COVID-19), caused by a previously unknown coronavirus ... -
Delays in HIV-1 infant PCR testing may leave children without confirmed diagnoses
(Stellenbosch : Stellenbosch University, 2021-12)Background The early diagnosis and confirmation of HIV infection in newborns is crucial for expedited antiretroviral therapy initiation. Confirmatory testing must be done for all children with a reactive HIV PCR result. ... -
Pediatric hiv-1 drug resistance in Botswana
(Stellenbosch : Stellenbosch University, 2021-12)ENGLISH ABSTRACT: Antiretroviral therapy (ART) treatment in pregnant women and new-borns for prevention of mother-to-child transmission (PMTCT) can result in Human Immunodeficiency Virus drug resistance (HIVDR) in paediatrics; ... -
Viral hepatitis B and C in HIV-exposed South African infants
(BMC (part of Springer Nature), 2020)Background: Whilst much attention is given to eliminating HIV mother-to-child transmission (MTCT), little has been done to ensure the same for hepatitis B virus (HBV) transmission. The introduction of HBV immunization at ...
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