South Africa has the largest worldwide HIV/AIDS population with 5.6 million people infected and at least 2 million people on
antiretroviral therapy. The majority of these infections are caused by HIV-1 subtype C. Using ...
Ithete, Ndapewa LaudikaStoffberg, SamanthaCorman, Victor MaxCottontail, Veronika M.Richards, Leigh RosanneSchoeman, M. CorrieDrosten, ChristianDrexler, Jan FelixPreiser, Wolfgang(Centers for Disease Control and Prevention (CDC), 2013-10)
We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV.
Andersson, M. I.Maponga, T. G.Ijaz, S.Barnes, J.Theron, G. B.Meredith, S. A.Preiser, W.Tedder, R. S.(Elsevier, 2013-11)
OBJECTIVES:
Persistent hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in sub-Saharan Africa. The HIV epidemic has the potential to affect its biology. Immunisation protocols established in ...
La Grange, Heleen(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Background: Sudden infant death syndrome (SIDS) is considered the second most frequent cause of infant mortality worldwide. Research specifically pertaining to SIDS is limited in the South African setting. ...
ENGLISH ABSTRACT: The emergence and re-emergence of viral human pathogens from wildlife sources in the recent past has led to increased studies and surveillance of wildlife for potentially zoonotic agents in order to gain ...
ENGLISH ABSTRACT: Chronic HIV-1 infection is characterized by extensive inflammation/immune activation and also by anaemia. Macrophages and neutrophils produce reactive oxygen species (ROS) which can cause damage to ...
ENGLISH ABSTRACT: The HIV epidemic in the past couple of decades has spread at an alarming rate throughout Southern Africa. Today the region accounts for roughly one third of all HIV infections, while prevalence rates in ...
Criteria that define low positive results on the COBAS® AmpliPrep/COBAS® TaqMan (CAP/CTM) HIV-
1 Qual test as inconclusive have been adopted by all academic centres in South Africa that conduct
infant HIV PCR, following ...
Oosthuysen, Wilhelm Frederick(Stellenbosch : Stellenbosch University, 2013-12)
ENGLISH ABSTRACT: Numerous studies conducted internationally have identified and described several endemic methicillin-susceptible Staphylococcus aureus (MSSA) clones. However, only some of these clones are associated with ...
Van Zyl, Gert U.Liu, Tommy F.Claassen, MathildaEngelbrecht, SusanDe Oliveira, TulioPreiser, WolfgangWood, Natasha T.Travers, SimonShafer, Robert W.(Public Library of Science -- PLoS, 2013-06)
Objectives: South Africa’s national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. ...
Adu, BrightDodoo, DanielAdukpo, Selorme.Gyan, Ben A.Hedley, Paula L.Goka, BamenlaAdjei, George O.Larsen, Severin O.Christiansen, MichaelTheisen, Michael(PLOS, 2011-12)
Background: Cerebral malaria (CM) is the most severe outcome of Plasmodium falciparum infection and a major cause of
death in children from 2 to 4 years of age. A hospital based study in Ghana showed that P. falciparum ...
The diversity of HIV-1 sequences derived from patients in Bushbuckridge, Mpumalanga, was investigated. The gag p24, pol p10 and p66/p51, pol p31 and env gp41 gene fragments from 51 patients were amplified and sequenced. ...
The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic
agents can be attributed to a high mutation rate and frequent recombination events.
These factors have collectively contributed to the ...
Background: Sub-Saharan Africa is the world’s worst HIV-AIDS affected region. More interventions to manage this
pandemic are urgently required. Transmission of the virus through an exchange of saliva is rarely known to ...
ENGLISH ABSTRACT: Despite the availability of Hepatitis B virus (HBV) vaccination for over three decades, this infection remains a major public health problem. Whilst the WHO recommends giving a birth dose of the vaccine, ...
ENGLISH ABSTRACT: Introduction
Acute respiratory tract infections cause significant morbidity and mortality worldwide, and are
the main reason for the utilisation of health care services. Identifying the aetiological ...
ENGLISH ABSTRACT: The gag gene of HIV-1 encodes for one of the major structural proteins, which
contains several conserved cytotoxic T cell (CTL) epitopes. Gag specific CTL
responses are important in controlling viral ...
ENGLISH ABSTRACT: Hepatitis B virus (HBV) immunisation protocols in much of Africa are based on data from the pre-human immunodeficiency virus (pre-HIV) era that indicated that HBV transmission occurs predominantly ...
Van Zyl, Gert Uves(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Introduction: Since the South African public sector antiretroviral roll-out programme started in 2004, the success of antiretroviral combination therapy (cART) has been experienced in terms of survival, ...
ENGLISH ABSTRACT: Background: The conventional sequence analysis is the most common method used for the detection of drug-resistant mutants. Due to its sensitivity limitations, it is unable to detect these mutants when ...