Medical Virology
Collections in this community
Recent Submissions
-
COVID-19 : getting ahead of the epidemic curve by early implementation of social distancing
(Health & Medical Publishing Group, 2020)The response to the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has largely been reactive. There are a few exceptions of countries ... -
Detectable HIV-1 in semen in individuals with very low blood viral loads
(BioMed Central, 2020-03-05)Background: Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive ... -
Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape
(Medpharm Publications, 2018)Background: The Nelson Mandela Academic Hospital (NMAH) in Mthatha, Eastern Cape, is a rural central hospital, serving one of the poorest districts in South Africa. The prevalence of and risk factors for congenital ... -
Hepatitis A in Nelson Mandela Bay and Sarah Baartman districts, Eastern Cape, South Africa
(Medpharm Publications, 2018)Background: Hepatitis A is the most common cause of acute viral hepatitis, not only in South Africa, but in many other countries. In South Africa, there is a lack of data regarding the true incidence of hepatitis A, and ... -
HIV-1 RNA testing of pooled dried blood spots is feasible to diagnose acute HIV infection in resource limited settings
(Medpharm Publications, 2018)Objectives: Rapid human immunodeficiency virus (HIV) antibody tests, routinely used for diagnosis in adults and older children in resource-limited settings (RLS), do not detect early HIV infections prior to seroconversion ... -
Investigating HIV-1 DNA and HIV-1 RNA kinetics with ultrasensitive assays in very early treated infants and determining predictors associated with kinetics in older treated children
(Stellenbosch : Stellenbosch University, 2019-12)Background The impact of early initiation of antiretroviral therapy (ART) on HIV-1 persistence has been characterised in adult cohorts and in well-suppressed children on continuous therapy. These studies have shown that ... -
Hepatitis B virus mother-to-child transmission in Namibia: transmission dynamics and possibilities for elimination
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: Introduction: Hepatitis B virus (HBV) remains endemic in sub-Saharan Africa (SSA). While the roll-out of pediatric HBV immunization from six weeks of age has had an impact on horizontal transmission of ... -
Modelling cost-effectiveness of tenofovir for prevention of mother to child transmission of hepatitis B virus (HBV) infection in South Africa
(BMC (part of Springer Nature), 2019-06-26)Background: International sustainable development goals for the elimination of viral hepatitis as a public health problem by 2030 highlight the need to optimize strategies for prevention, diagnosis and treatment of hepatitis ... -
Point-of-care screening for hepatitis B virus infection in pregnant women at an antenatal clinic : a South African experience
(Public Library of Science, 2017)Background & aims: Elimination of HIV and syphilis mother-to-child transmission (MTCT) has received much attention but little consideration has been given to the possibility of elimination of HBV MTCT. In sub-Saharan ... -
Molecular characterisation of HIV-1 recombinants and non-subtype C viruses in South Africa
(Stellenbosch : Stellenbosch University, 2019-02)ENGLISH ABSTRACT: HIV/AIDS is a severe health burden, affecting 36.9 million people worldwide by the end of 2017. South Africa has the largest HIV-1 epidemic in the world, estimated at 7.2 million infected individuals ... -
Development of functional immune readouts for the confirmation of mendelian susceptibility to mycobacterial disease and related primary immunodeficiencies
(Stellenbosch : Stellenbosch University, 2019-04)Background: Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalence ... -
Investigating the host range of Neoromicia capensis coronavirus in vitro
(2019-04)ENGLISH ABSTRACT: Coronaviruses are known to cause disease in humans and animals. Two important human coronaviruses that have caused epidemics are severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East ... -
Hepatitis b virus-related hepatocellular carcinoma in south africa: investigations into the risk profile of a previously unscreened population from the Western Cape
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Hepatocellular carcinoma (HCC) is a neglected major public health problem worldwide. In SubSaharan Africa (SSA), most HCC cases are diagnosed with advanced disease, well past the timing of possible ... -
Dried plasma spot testing – the answer for making blood transfusion testing safer in africa?
(Stellenbosch : Stellenbosch University, 2018-12)ENGLISH ABSTRACT: Sub-Saharan Africa (SSA) has a unique set of challenges pertaining to blood transfusion. Two of the largest contributing factors are: (1) the most common disease states in SSA require large amounts of ... -
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation
(Public Library of Science, 2017-07-28)Introduction: HIV-1 genotypic resistance test (GRT) interpretation systems (IS) require updates as new studies on HIV-1 drug resistance are published and as treatment guidelines evolve. Methods: An expert panel was ... -
Hepatitis B virus infection as a neglected tropical disease
(Public Library of Science, 2017-10-05)ENGLISH ABSTRACT: The Global Hepatitis Health Sector Strategy is aiming for “elimination of viral hepatitis as a public health threat” by 2030 [1], while enhanced elimination efforts for hepatitis are also promoted under ... -
Barriers to HIV remission research in low- and middle-income countries
(Wiley Open Access, 2017)Introduction: HIV eradication and remission research has largely taken place in high-income countries. In low- and middleincome countries (LMIC), there may be factors that have a substantial impact on the size of the ... -
Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaounde, Cameroon
(European HIV/AIDS and Infectious Diseases Academy, 2017)Introduction: The emergence of drug resistance mutations (DRMs) has been a major threat for successful lifelong combination antiretroviral therapy (cART), especially for HIV-vertically infected children within the context ... -
Mutational correlates of virological failure in individuals receiving a WHO-recommended tenofovir-containing first-line regimen : an international collaboration
(Elsevier, 2017)Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, ... -
HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa
(BioMed Central, 2018-05-08)Background: Co-infection with HIV negatively impacts the progression of chronic hepatitis B virus (HBV) infection, including causing rapid progression to liver fibrosis. Sub-Saharan Africa represents arguably the most ...
RSS 1.0