• A study of the prevalence of Hepatitis B virus infection in the infants of HIV-positive mothers participating in P1041 in South Africa 

  Tamandjou, Cynthia Raissa (Stellenbosch : Stellenbosch University, 2014-12)

  ENGLISH ABSTRACT: Despite the decreased rate of HBV horizontal transmission in South Africa (SA) due to the HB vaccine, the risk of perinatal transmission remains of concern, especially in HIV/HBV co-infected women. Loss ...
• Monocytes in chronic HIV-1 infection : changes in phenotypic marker expression and their relationship with immune activation 

  Poovan, Karmistha (Stellenbosch : Stellenbosch University, 2014-12)

  ENGLISH ABSTRACT: HIV-infection is characterized by depletion of CD4+ T-cells from the gut-associated lymphoid tissue (GALT) which causes irreparable gastrointestinal tract damage and subsequent microbial translocation of ...
• Pooled HIV-1 Viral Load Testing Using Dried Blood Spots to Reduce the Cost of Monitoring Antiretroviral Treatment in a Resource-Limited Setting 

  Pannus, Pieter   Fajardo, Emmanuel   Metcalf, Carol   Coulborn, Rebecca M.   Duran, Laura T.   Bygrave, Helen   Ellman, Tom   Garone, Daniela   Murowa, Michael   Mwenda, Reuben   Reid, Tony   Preiser, Wolfgang (Lippincott Williams & Wilkins Open Access, 2013-10)

  Rollout of routine HIV-1 viral load monitoring is hampered by high costs and logistical difficulties associated with sample collection and transport. New strategies are needed to overcome these constraints. Dried blood ...
• HIV-1 Subtypes B and C Unique Recombinant Forms (URFs) and transmitted drug resistance identified in the Western Cape Province, South Africa 

  Jacobs, Graeme. Brendon   Wilkinson, Eduan   Isaacs, Shahieda   Spies, Georgina   De Oliveira, Tulio   Seedat, Soraya   Engelbrecht, Susan (Public Library of Science, 2014-03)

  South Africa has the largest worldwide HIV/AIDS population with 5.6 million people infected and at least 2 million people on antiretroviral therapy. The majority of these infections are caused by HIV-1 subtype C. Using ...
• Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa 

  Ithete, Ndapewa Laudika   Stoffberg, Samantha   Corman, Victor Max   Cottontail, Veronika M.   Richards, Leigh Rosanne   Schoeman, M. Corrie   Drosten, Christian   Drexler, Jan Felix   Preiser, Wolfgang (Centers for Disease Control and Prevention (CDC), 2013-10)

  We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV.
• The epidemiology of hepatitis B virus infection in HIV-infected and HIV-uninfected pregnant women in the Western Cape, South Africa 

  Andersson, M. I.   Maponga, T. G.   Ijaz, S.   Barnes, J.   Theron, G. B.   Meredith, S. A.   Preiser, W.   Tedder, R. S. (Elsevier, 2013-11)

  OBJECTIVES: Persistent hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in sub-Saharan Africa. The HIV epidemic has the potential to affect its biology. Immunisation protocols established in ...
• Respiratory pathogens in cases of Sudden Unexpected Death in Infancy (SUDI) at Tygerberg forensic pathology service mortuary 

  La Grange, Heleen (Stellenbosch : Stellenbosch University, 2014-04)

  ENGLISH ABSTRACT: Background: Sudden infant death syndrome (SIDS) is considered the second most frequent cause of infant mortality worldwide. Research specifically pertaining to SIDS is limited in the South African setting. ...
• Investigation of small mammal-borne viruses with zoonotic potential in South Africa 

  Ithete, Ndapewa Laudika (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: The emergence and re-emergence of viral human pathogens from wildlife sources in the recent past has led to increased studies and surveillance of wildlife for potentially zoonotic agents in order to gain ...
• Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia 

  Loots, Stanley (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Chronic HIV-1 infection is characterized by extensive inflammation/immune activation and also by anaemia. Macrophages and neutrophils produce reactive oxygen species (ROS) which can cause damage to ...
• Origin and phylodynamics of HIV-1 subtype C in South Africa 

  Wilkinson, Eduan (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: The HIV epidemic in the past couple of decades has spread at an alarming rate throughout Southern Africa. Today the region accounts for roughly one third of all HIV infections, while prevalence rates in ...
• Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test are qualitatively different from confirmed positive results 

  Maritz, Jean (2013-10)

  Criteria that define low positive results on the COBAS® AmpliPrep/COBAS® TaqMan (CAP/CTM) HIV- 1 Qual test as inconclusive have been adopted by all academic centres in South Africa that conduct infant HIV PCR, following ...
• Population structure, host cell interactions and pathogenesis of Staphylococcus aureus strains isolated at Tygerberg hospital, South Africa 

  Oosthuysen, Wilhelm Frederick (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Numerous studies conducted internationally have identified and described several endemic methicillin-susceptible Staphylococcus aureus (MSSA) clones. However, only some of these clones are associated with ...
• Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens 

  Van Zyl, Gert U.   Liu, Tommy F.   Claassen, Mathilda   Engelbrecht, Susan   De Oliveira, Tulio   Preiser, Wolfgang   Wood, Natasha T.   Travers, Simon   Shafer, Robert W. (Public Library of Science -- PLoS, 2013-06)

  Objectives: South Africa’s national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. ...
• Polymorphisms in the RNASE3 Gene Are Associated with Susceptibility to Cerebral Malaria in Ghanaian Children 

  Adu, Bright   Dodoo, Daniel   Adukpo, Selorme.   Gyan, Ben A.   Hedley, Paula L.   Goka, Bamenla   Adjei, George O.   Larsen, Severin O.   Christiansen, Michael   Theisen, Michael (PLOS, 2011-12)

  Background: Cerebral malaria (CM) is the most severe outcome of Plasmodium falciparum infection and a major cause of death in children from 2 to 4 years of age. A hospital based study in Ghana showed that P. falciparum ...
• Phylogenetic analysis of HIV-1 in Mpumalanga 

  Msimanga, Wela Patrick (Stellenbosch : Stellenbosch University, 2013-03)

  The diversity of HIV-1 sequences derived from patients in Bushbuckridge, Mpumalanga, was investigated. The gag p24, pol p10 and p66/p51, pol p31 and env gp41 gene fragments from 51 patients were amplified and sequenced. ...
• The apoptotic potential of different HIV-1 subtype C Tat mutations in cell culture 

  Isaacs, Shahieda (Stellenbosch : Stellenbosch University, 2013-03)

  The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic agents can be attributed to a high mutation rate and frequent recombination events. These factors have collectively contributed to the ...
• The role of crude saliva and purified salivary mucins in the inhibition of the Human Immunodeficiency Virus type 1 

  Peacocke, Julia   Lotz, Zoe   de Beer, Corena   Roux, Paul   Mall, Anwar S (BioMed Central, 2012-08)

  Background: Sub-Saharan Africa is the world’s worst HIV-AIDS affected region. More interventions to manage this pandemic are urgently required. Transmission of the virus through an exchange of saliva is rarely known to ...
• The prevalence of Hepatitis B virus infection in an HIV-exposed paediatric cohort from the Western Cape, South Africa 

  Chotun, Bibi Nafiisah (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Despite the availability of Hepatitis B virus (HBV) vaccination for over three decades, this infection remains a major public health problem. Whilst the WHO recommends giving a birth dose of the vaccine, ...
• Investigating the aetiology of respiratory tract infections in children admitted to Tygerberg Children’s Hospital using molecular methods and viral culture 

  Maree, Leana (Stellenbosch : Stellenbosch University, 2012-12)

  ENGLISH ABSTRACT: Introduction Acute respiratory tract infections cause significant morbidity and mortality worldwide, and are the main reason for the utilisation of health care services. Identifying the aetiological ...
• The characterisation and expression of HIV-1 subtype C gag 

  Sampson, Candice Corene (Stellenbosch : Stellenbosch University, 2002)

  ENGLISH ABSTRACT: The gag gene of HIV-1 encodes for one of the major structural proteins, which contains several conserved cytotoxic T cell (CTL) epitopes. Gag specific CTL responses are important in controlling viral ...

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