Medical Microbiology
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Rapid diagnosis of cryptococcal meningitis by use of lateral flow assay on cerebrospinal fluid samples : influence of the high-dose “hook” effect
(American Society for Microbiology, 2014)Cryptococcal meningitis is the most frequent cause of meningitis and a major cause of mortality in HIV-infected adults in Africa. This study evaluated the performance of the lateral flow assay (LFA) on cerebrospinal fluid ...
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The routine paediatric human immunodeficiency virus visit as an intervention opportunity for failed maternal care, and use of point-of-care CD4 testing as an adjunct in determining antiretroviral therapy eligibility
(Medpharm Publications, 2014)South African women and children remain at the centre of the human immunodeficiency virus (HIV) pandemic, and maternal well-being plays a critical role in child health. In this study, we evaluated the impact of the paediatric ...
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Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ...
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In vitro activity of tigecycline and comparators against Gram-positive and Gram-negative isolates collected from the Middle East and Africa between 2004 and 2011
(Elsevier, 2014)The Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) was established in 2004 to monitor longitudinal changes in bacterial susceptibility to numerous antimicrobial agents, specifically tigecycline. In this study, ...
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National sentinel site surveillance for antimicrobial resistance in Klebsiella pneumoniae isolates in South Africa, 2010-2012
(Health & Medical Publishing Group, 2014-08)Background. The increasing rates of antimicrobial resistance observed in the nosocomial pathogen Klebsiella pneumoniae are of major public health concern worldwide. Objectives. To describe the antibiotic susceptibility ...
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Molecular diagnostic approach to determine the degree of photoaging of the skin
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Context: Excessive exposure to ultraviolet radiation (UV) results in the risk of acquiring long-term harmful effects such as photoaging, which is characterised by deep wrinkles, roughness, dyspigmentation ...
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Biofilm formation in invasive Staphylococcus aureus isolates is associated with the clonal lineage
(Stellenbosch : Stellenbosch UniversityElsevier, 2016-01)ENGLISH ABSTRACT: Objectives: The ability to form biofilms contributes significantly to the virulence of Staphylococcus aureus. Virulence factors may be associated with certain S. aureus lineages. However, the contribution ...
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Pneumocystis pneumonia in South African children diagnosed by molecular methods
(BioMed Central, 2014-01)Abstract Background Pneumocystis pneumonia (PCP) is an important cause of hospitalization and mortality in HIV-infected children. However, the incidence of PCP has been underestimated ...
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Management of uncomplicated malaria
(Health and Medical Publishing Group (HMPG), 2008-06)The key issues in the successful management of malaria are early and accurate diagnosis and urgent treatment with effective drugs. Disease presentation is, however, not specific – progression to complicated disease may ...
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Sarcomeric modifiers of hypertrophy in hypertrophic cardiomyopathy (HCM)
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular morbidity and allcause mortality. Significantly, it is considered a modifiable cardiovascular risk factor as its regression ...
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Treatment and prevention of trichuriasis : efficacy of albendazole in disadvantaged children at Rawsonville Primary School, Western Cape Province, South Africa
(Stellenbosch : Stellenbosch University, 2000-12)ENGLISH ABSTRACT: Children in socioeconomically disadvantaged communities in the Western Cape and elsewhere in South Africa are frequently infected by Trichuris trichiura. Although albendazole and mebendazole are listed as ...
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The relevance of apoptosis in the pathogenesis of human immunodeficiency virus-1 disease
(Stellenbosch : Stellenbosch University, 2004-12)ENGLISH ABSTRACT: A simple and rapid scatter-based flow cytometric assay was developed to detect apoptosis in CD4+ and CD8+ T cells from a mixed population of cells. The assay was suitable for children. Apoptotic PBMCs ...
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Development and validation of stabilized whole blood samples expressing T-cell activation markers as quality control reference material
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: Introduction: Flow cytometry has progressively replaced many traditional laboratory tests due to its greater accuracy, sensitivity and rapidity in the routine clinical settings especially clinical trails. ...
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Development and validation of an in vitro model of dendritic cell identification and activation
(Stellenbosch : Stellenbosch University, 2008-03)ENGLISH ABSTRACT: The aim of this study was to investigate the effect of MBV and Coley’s Toxin on dendritic cells in vitro. The dendritic cell system of antigen presenting cells is the initiator and modulator of the ...
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Longitudinal investigation of vaccine specific antibody levels and cellular markers of adaptive immune responses in HIV Exposed Uninfected (HEU) and Unexposed (UE) infants
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Background: In South Africa alone, 30% of women of child-bearing age are infected with HIV. With the increasing focus and success of prevention of mother-to-child transmission (PMTCT) programmes, an ...
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Biofilm formation and adherence characteristics of an Elizabethkingia meningoseptica isolate from Oreochromis mossambicus
(BioMed Central, 2011-05-05)ABSTRACT: Background. Elizabethkingia spp. are opportunistic pathogens often found associated with intravascular device-related bacteraemias and ventilator-associated pneumonia. Their ability to exist as biofilm structures ...
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The intimate relationship between man and yeast : it's complicated
(Stellenbosch : University of Stellenbosch, 2011-06)Inaugural address delivered on 6 June 2011 by prof Alf Botha.Yeasts public health service; resource allocation; have been associated with mankind’s welfare for a long time. For millennia these unicellular fungi were ...
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An appraisal of the uricult dip slide method in the diagnosis of urinary infections
(HMPG, 1973-05)Uricult dip slide urine cultures were compared with standard laboratory plate cultures. Good agreement of bacterial counts was obtained after incubation at 37°C but not at room temperature. Tests of therapeutic activity ...
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Antibiotic-resistant Serratia marcescens infection in a hospital
(HMPG, 1979-04)Over a 12-month period, 74 isolates of Serratia marcescens were obtained from various sources at Tygerberg Hospital. The majority of these isolates were from catheterized patients with urinary tract infections, and ...
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Involving African traditional health practitioners in HIV/AIDS interventions
(Health and Medical Publishing Group (HMPG), 2008)[No abstract available]
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Potential for nosocomial transmission of multidrug-resistant (MDR) tuberculosis in a South African tertiary hospital
(Health and Medical Publishing Group (HMPG), 2010)Background. Tuberculosis (TB) is a major health problem in the Western Cape, with an incidence exceeding 900 per 100 000 people. Nosocomial transmission of TB, and particularly drug-resistant TB, is a potential risk that ...
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Differentiation of Klebsiella Enterobacter Serratia organisms
(Health and Medical Publishing Group (HMPG), 1975)Differentiation of 625 strains of bacteria which fulfilled the requirements laid down for the definition of Klebsielleae was carried out using 6 biochemical tests. 546 strains were identified as members of the genus ...
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Sequence-based molecular diagnosis of X-linked agammaglobulinemia in South African individuals
(Stellenbosch : University of Stellenbosch, 2011-03-04)ENGLISH SUMMARY: Background: Primary immunodeficiency disorders (PID) disrupt the proper functioning of the immune system. The prototypic PID is X-linked Agammaglobulinemia (XLA). This disorder is caused by mutations in ...
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Elucidation of the substrates of mycosin 3, an essential protease of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects one third of the world’s population and kills 1.7 million people per year. The increasing prevalence of multi- and extensively ...
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High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town, South Africa
(BioMed Central, 2008-04)Background: There is little information on nasopharyngeal (NP) flora or bacteremia in HIV-infected children. Our aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective ...
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Epidemiology and antibiotic susceptibility patterns of mycoplasma sp. and ureaplasma urealyticum
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Overview: Mycoplasmas and ureaplasmas are not routinely diagnosed and are under researched in South Africa. Prevalence, population shifts especially concerning genital flora and implications in infection ...
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In Vitro antimicrobial synergy testing of Acinetobachter Baumannii
(Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Acinetobacter baumannii has emerged as one of the most troublesome nosocomial pathogens globally. This organism causes infections that are often extremely difficult to treat because of the widespread ...
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Improving laboratory techniques to detect M. tuberculosis complex and C. neoformans as the causative agents of chronic meningitis in cerebrospinal fluid of adult patients.
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: INTRODUCTION Mycobacterium tuberculosis (MTB) and Cryptococcus neoformans are the most common causes of chronic meningitis in South Africa. Conventional microbiology has limited utility in diagnosing ...
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Genotypic characterization of Staphylococcus aureus isolates causing bacteraemia in patients admitted to Tygerberg Hospital, Western Cape Province, South Africa
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: S. aureus causes serious infections in the hospital and community settings. The rate of MRSA infections are rapidly increasing worldwide. Currently, at Tygerberg hospital, approximately a third of S. ...
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