Medical Microbiology
Collections in this community
Recent Submissions
-
Comparison of commercial assays and two-step approach to detect Clostridioides difficile in South Africa
(AOSIS, 2022-09)Background: Clostridioides difficile is the number one cause of hospital-acquired diarrhoea. Accurate diagnosis of C. difficile is of utmost importance as it guides patient management and infection control practices. Studies ... -
The association between pathogen factors and clinical outcomes in patients with Staphylococcus aureus bacteraemia in a tertiary hospital, Cape Town
(Elsevier, 2019-11)Background: Staphylococcus aureus is a serious pathogen, able to cause life-threatening infections such as bacteraemia. The association between S. aureus microbial characteristics and clinical outcomes is under-investigated ... -
Clonal expansion of colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa
(Elsevier, 2020-02)Objectives: To describe colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa. Methods: A. baumannii isolates identified on Vitek 2 Advanced Expert System were collected from Tygerberg Hospital ... -
Association between clinical and environmental factors and the gut microbiota profiles in young South African children
(Nature Research (part of Springer Nature), 2021)ENGLISH ABSTRACT: Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each ... -
Optimizing antibiotic prescribing : collective approaches to managing a common-pool resource
(Wiley, 2019)Background: Antimicrobial resistance (AMR) is one of the greatest threats in 21st century medicine. AMR has been characterized as a social dilemma. A familiar version describes the situation in which a collective resource ... -
Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial
(Elsevier, 2019)Background: New anti-tuberculosis regimens that are shorter, simpler, and less toxic than those that are currently available are needed as part of the global effort to address the tuberculosis epidemic. We aimed to investigate ... -
Carbapenemase-producing Enterobacteriaceae colonisation in adult inpatients : a point prevalence study
(AOSIS, 2019)Background: Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) have been increasing worldwide in recent years, but data regarding the prevalence and clinical significance of CPE colonisation in South ... -
Clonal expansion of colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa
(Elsevier, 2020)Objectives: To describe colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa. Methods: A. baumannii isolates identified on Vitek 2 Advanced Expert System were collected from Tygerberg Hospital ... -
Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
(AOSIS, 2021)ENGLISH ABSTRACT: Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage ... -
Characterisation of mcr-4.3 in a colistin-resistant Acinetobacter nosocomialis clinical isolate from Cape Town, South Africa
(Elsevier, 2021)Objectives: Colistin resistance in Acinetobacter spp. is increasing, resulting in potentially untreatable noso- comial infections. Plasmid-mediated colistin resistance is of particular concern due to its low fitness cost ... -
Characterisation of mobile colistin resistance genes (mcr‑3 and mcr‑5) in river and storm water in regions of the Western Cape of South Africa
(BMC (part of Springer Nature), 2021)Background: Colistin is regarded as a last-resort antimicrobial against multi-drug resistant Gram-negative bacteria (GNB), therefore the dissemination of colistin resistance in the environment is of great concern. Horizontal ... -
Bacterial infection, antibiotic use and COVID-19 : lessons from the intensive care unit
(Health & Medical Publishing Group, 2021-04-14)Background. Empirical broad-spectrum antibiotics are frequently prescribed to patients with severe COVID-19, motivated by concern about bacterial coinfection. There is no evidence of benefit from such a strategy, while the ... -
Characterisation of fosfomycin resistance in urinary pathogens from the Western Cape, South Africa.
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Introduction: Urinary tract infections (UTI) are the most commonly acquired bacterial infections worldwide. The South African Department of Health advised that fosfomycin, nitrofurantoin and gentamicin ... -
The Characterisation of Antibiotic Resistance Plasmids in Escherichia coli and Klebsiella pneumoniae Isolates from Hospital and Community Settings
(Stellenbosch : Stellenbosch University, 2021-03)ENGLISH ABSTRACT: Antimicrobial resistance has become one of the biggest challenges and threats to public health systems worldwide. Widespread distribution of resistance is commonly due to horizontal gene transfer, which ... -
Investigating the role of respiratory co-infections and the nasopharyngeal microbiome in children with suspected pulmonary tuberculosis
(Stellenbosch : Stellenbosch University, 2020-12)Introduction: Tuberculosis (TB) is a global health problem, causing morbidity, mortality and devastating social and economic impacts. Pediatric TB is particularly challenging due to difficulties in diagnosis. ... -
The effect of storage conditions on microbial communities in stool
(Public Library of Science, 2020)Microbiome research has experienced a surge of interest in recent years due to the advances and reduced cost of next-generation sequencing technology. The production of high quality and comparable data is dependent on ... -
The association between pathogen factors and clinical outcomes in patients with Staphylococcus aureus bacteraemia in a tertiary hospital, Cape Town
(Elsevier on behalf of International Society for Infectious Diseases, 2019-11-29)Background: Staphylococcus aureus is a serious pathogen, able to cause life-threatening infections such as bacteraemia. The association between S. aureus microbial characteristics and clinical outcomes is under- investigated ... -
The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa
(BMC (part of Springer Nature), 2020-03-14)Abstract Background: Antimicrobial resistance is an increasingly serious problem in public health globally. Monitoring resistance levels within healthcare and community settings is critical to combat its ongoing increase. ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Optimisation and comparison of a phenotypic maldi-tof assay with molecular and phenotypic methods for the rapid identification of selected fungal, nocardia and nontuberculous mycobacteria.
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been utilised in clinical microbiology laboratories for several years, but is mostly used for the rapid and ...
RSS 1.0