Medical Microbiology
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Investigating the role of respiratory co-infections and the nasopharyngeal microbiome in children with suspected pulmonary tuberculosis
(Stellenbosch : Stellenbosch University, 2020-12)Introduction: Tuberculosis (TB) is a global health problem, causing morbidity, mortality and devastating social and economic impacts. Pediatric TB is particularly challenging due to difficulties in diagnosis. ... -
The effect of storage conditions on microbial communities in stool
(Public Library of Science, 2020)Microbiome research has experienced a surge of interest in recent years due to the advances and reduced cost of next-generation sequencing technology. The production of high quality and comparable data is dependent on ... -
The association between pathogen factors and clinical outcomes in patients with Staphylococcus aureus bacteraemia in a tertiary hospital, Cape Town
(Elsevier on behalf of International Society for Infectious Diseases, 2019-11-29)Background: Staphylococcus aureus is a serious pathogen, able to cause life-threatening infections such as bacteraemia. The association between S. aureus microbial characteristics and clinical outcomes is under- investigated ... -
The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa
(BMC (part of Springer Nature), 2020-03-14)Abstract Background: Antimicrobial resistance is an increasingly serious problem in public health globally. Monitoring resistance levels within healthcare and community settings is critical to combat its ongoing increase. ... -
B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Optimisation and comparison of a phenotypic maldi-tof assay with molecular and phenotypic methods for the rapid identification of selected fungal, nocardia and nontuberculous mycobacteria.
(Stellenbosch : Stellenbosch University, 2020-03)ENGLISH ABSTRACT: Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been utilised in clinical microbiology laboratories for several years, but is mostly used for the rapid and ... -
The carriage of antimicrobial resistance in community children – a TB-CHAMP sub-study.
(Stellenbosch : Stellenbosch University., 2019-12)Introduction: The world-wide rise in antimicrobial resistance (AMR) is threatening the effectivity of antibiotics and the control of infectious diseases. The challenge of AMR is considerably exacerbated by the presence ... -
One Health approach in the prevention and control of mycobacterial infections in Tanzania : lessons learnt and future perspectives
(BMC (part of Springer Nature), 2019-11-27)Background: One Health (OH) is an integrated approach, formed inclusive of using multiple disciplines to attain optimal health for humans, animals, and the environment. The increasing proximity between humans, livestock, ... -
Laboratory based antimicrobial resistance surveillance for Pseudomonas aeruginosa blood isolates from South Africa
(Journal of Infection in Developing Countries, 2018)Introduction: Antimicrobial resistant bacterial infections are widespread globally and increases in antimicrobial resistance presents a major threat to public health. Pseudomonas aeruginosa is an opportunistic healthcare ... -
Whole-genome sequence of a mycobacterium goodii isolate from a pediatric patient in South Africa
(American Society for Microbiology, 2018)ENGLISH ABSTRACT: We describe here the draft genome sequence of a Mycobacterium goodii isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported genome of this rapidly ... -
The carriage of antibiotic resistant Gram-negative organisms in children in the Cape Town community and the impact of antibiotic exposure on the development of resistance (a TB-CHAMP sub-study)
(Stellenbosch : Stellenbosch University, 2019-12)Introduction Antibiotic resistance has become a major issue across the globe and the situation is worsening in low- and middle-income countries. In sub-Saharan Africa and the world at large, antibiotic resistance research ... -
Xenorhabdus khoisanae SB10 produces Lys-rich PAX lipopeptides and a Xenocoumacin in its antimicrobial complex
(BMC (part of Springer Nature), 2019-06-13)Background: Xenorhabdus spp. live in close symbiosis with nematodes of the Steinernema genus. Steinernema nematodes infect an insect larva and release their symbionts into the haemocoel of the insect. Once released into the ... -
The epidemiology and virulence characteristics of Staphylococcus aureus isolates from bacteraemic patients at Tygerberg Hospital, South Africa
(Stellenbosch : Stellenbosch University, 2019-04-02)ENGLISH ABSTRACT: Introduction: Staphylococcus aureus is a versatile pathogen that produces multiple virulence factors which work together to establish and maintain infections. The accessory gene regulator (agr) locus is ... -
Development of functional immune readouts for the confirmation of mendelian susceptibility to mycobacterial disease and related primary immunodeficiencies
(Stellenbosch : Stellenbosch University, 2019-04)Background: Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic mycobacteria. In countries with a high prevalence ... -
Surveillance of healthcare-associated infection in hospitalised South African children : Which method performs best?
(Health & Medical Publishing Group, 2017)Background. In 2012, the South African (SA) National Department of Health mandated surveillance of healthcare-associated infection (HAI), but made no recommendations of appropriate surveillance methods. Methods. Prospective ... -
Beta-lactam resistance mechanisms in Enterobacter species isolates from Tygerberg Hospital.
(Stellenbosch : Stellenbosch University, 2018-10-31)Background Resistance to carbapenem antibiotics in Gram-negative bacteria is a major public health problem due to limited treatment options. In Enterobacter species, carbapenemase production and reduced membrane permeability, ... -
Stool culture for diagnosis of pulmonary tuberculosis in children
(American Society for Microbiology, 2017-12)Bacteriological confirmation of Mycobacterium tuberculosis is achieved in the minority of young children with tuberculosis (TB), since specimen collection is resource intensive and respiratory secretions are mostly ... -
Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa : phenotypic and genotypic analysis of isolates
(BioMed Central, 2017-9)Background: Workers in clinical microbiology laboratories are exposed to a variety of pathogenic microorganisms. Salmonella species is among the most commonly reported bacterial causes of laboratory-acquired infections. ... -
Molecular detection of Mycobacterium tuberculosis in stool of children with suspected intrathoracic tuberculosis
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY: The bacteriological confirmation of tuberculosis in children is challenging. The current diagnostic gold standard, liquid culture of respiratory specimens, has low sensitivity in paucibacillary paediatric ... -
The epidemiology of Gram negative bacteraemia at Tygerberg Hospital
(Stellenbosch : Stellenbosch University, 2018-03)Background Escherichia coli and Klebsiella pneumoniae are common causes of Bloodstream Infections (BSI). β-lactam antibiotics, such as cephalosporins and carbapenems, are commonly used to treat these infections. Increasing ...
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